Analytical Data
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基因名
ELMO3
- Application
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别名
ELMO3；Engulfment and cell motility Protein 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96BJ8
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表达区间
1-720aa
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氨基酸序列
MAPPRNVVKI AIKMRDAIPQ LIQLDQAKPL AAVLKEVCDA WSLTHSERYA LQFADGHRRY ITENNRAEIK NGSILCLSTA PDLEAEQLLG GLQSNSPEGR REALRRLVPL ASDMIFAREV ISRNGLQILG TIIEDGDDLG EVLALSLRAF SELMEHGVVS WETLSIPFVR KVVCYVNMNL MDASVPPLAL GLLESVTLSS PALGQLVKSE VPLDRLLVHL QVMNQQLQTK AMALLTALLQ GASPVERKHM LDYLWQRNLR QFIYKNIIHS AAPMGDEMAH HLYVLQALML GLLEPRMRTP LDPYSQEQRE QLQVLRQAAF EVEGESSGAG LSADRRRSLC AREFRKLGFS NSNPAQDLER VPPGLLALDN MLYFSRNAPS AYSRFVLENS SREDKHECPF ARGSIQLTVL LCELLRVGEP CSETAQDFSP MFFGQDQSFH ELFCVGIQLL NKTWKEMRAT QEDFDKVMQV VREQLARTLA LKPTSLELFR TKVNALTYGE VLRLRQTERL HQEGTLAPPI LELREKLKPE LMGLIRQQRL LRLCEGTLFR KISSRRRQDK LWFCCLSPNH KLLQYGDMEE GASPPTLESL PEQLPVADMR ALLTGKDCPH VREKGSGKQN KDLYELAFSI SYDRGEEEAY LNFIAPSKRE FYLWTDGLSA LLGSPMGSEQ TRLDLEQLLT METKLRLLEL ENVPIPERPP PVPPPPTNFN FCYDCSIAEP
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分子量
81.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ELMO3 (Engulfment and Cell Motility 3) is a member of the ELMO family of proteins, which are implicated in several cellular processes, including cell migration, phagocytosis, and cytoskeletal remodeling. Research into ELMO3 has gained momentum due to its involvement in various physiological and pathological processes such as neuronal development, immune response, and cancer progression. ELMO3 functions as a guanine nucleotide exchange factor (GEF) for the small GTPase Rac1, thereby regulating actin dynamics and influencing cell movement and morphology. Abnormal expression or dysfunction of ELMO3 has been linked to several diseases, including neurodegenerative disorders and malignancies, making it a potential biomarker and therapeutic target. The study of recombinant ELMO3 protein is crucial for elucidating its structure-function relationships and understanding its role in cellular signaling pathways. Furthermore, insights gained from ELMO3 research may contribute to the development of novel treatment strategies for diseases characterized by impaired cell motility or abnormal apoptosis. As such, recombinant ELMO3 protein serves as an important tool for both basic research and therapeutic development, underscoring the need for comprehensive investigations into its functional mechanisms and potential applications in medicine.
