Analytical Data
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Gene name
SCN3B
- Application
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Alternative Names
SCN3B;KIAA1158;Sodium channel regulatory subunit beta-3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NY72
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Expression Region
23-159aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSFPVCVEV PSETEAVQGN PMKLRCISCM KREEVEATTV VEWFYRPEGG KDFLIYEYRN GHQEVESPFQ GRLQWNGSKD LQDVSITVLN VTLNDSGLYT CNVSREFEFE AHRPFVKTTR LIPLRVTEEA GEDFTSVVSE
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Molecular Weight
18 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SCN3B, a member of the sodium channel beta subunit family, plays a crucial role in modulating the function of voltage-gated sodium channels (VGSCs). These channels are essential for the generation and propagation of action potentials in excitable tissues, including the heart and nervous system. Research has indicated that SCN3B can influence the kinetics, voltage dependence, and stability of sodium channels, thereby affecting neuronal excitability and conduction velocity. Dysregulation of SCN3B expression has been linked to various pathological conditions, including epilepsy, cardiac arrhythmias, and other neurological disorders. The recombinant expression of SCN3B protein has become a vital tool for elucidating its functional roles and interactions with different sodium channel alpha subunits. By studying the recombinantly expressed SCN3B, researchers aim to better understand its structural and functional properties, as well as its potential as a therapeutic target for diseases associated with sodium channel dysfunction. The ongoing investigations into SCN3B function and its implications in health and disease underscore the importance of this protein in both basic and translational science.
