Analytical Data
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Gene name
NOC4L
- Application
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Alternative Names
NOC4L; Nucleolar complex protein 4 homolog; NOC4 protein homolog; NOC4-like protein; Nucleolar complex-associated protein 4-like protein
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BVI4
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Expression Region
1-516 aa
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AA Sequence
MEREPGAAGVRRALGRRLEAVLASRSEANAVFDILAVLQSEDQEEIQEAVRTCSRLFGALLERGELFVGQLPSEEMVMTGSQGATRKYKVWMRHRYHSCCNRLGELLGHPSFQVKELALSALLKFVQLEGAHPLEKSKWEGNYLFPRELFKLVVGGLLSPEEDQSLLLSQFREYLDYDDTRYHTMQAAVDAVARVTGQHPEVPPAFWNNAFTLLSAVSLPRREPTVSSFYVKRAELWDTWKVAHLKEHRRVFQAMWLSFLKHKLPLSLYKKVLLIVHDAILPQLAQPTLMIDFLTRACDLGGALSLLALNGLFILIHKHNLEYPDFYRKLYGLLDPSVFHVKYRARFFHLADLFLSSSHLPAYLVAAFAKRLARLALTAPPEALLMVLPFICNLLRRHPACRVLVHRPHGPELDADPYDPGEEDPAQSRALESSLWELQALQRHYHPEVSKAASVINQALSMPEVSIAPLLELTAYEIFERDLKKKGPEPVPLEFIPAQGLLGRPGELCAQHFTLS
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Molecular Weight
84.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NOC4L (Nucleolar Complex Related 4-Like) protein plays a crucial role in ribosome biogenesis and has been implicated in cellular stress responses, particularly in relation to the nucleolus, a subnuclear structure essential for ribosomal RNA synthesis and ribosome assembly. Research into NOC4L has gained momentum due to its association with various cellular processes, including gene expression regulation and cell cycle progression. Abnormalities in its function have been linked to several diseases, including cancer, highlighting the importance of understanding NOC4L's molecular mechanisms. Studies suggest that NOC4L may interact with other nucleolar proteins and ribonucleoprotein complexes, influencing their stability and function. Recent investigations aim to elucidate these interactions and their implications for ribosome production under both normal and stress conditions, providing insights into how cells adapt to environmental challenges. This research is not only vital for understanding fundamental cellular biology but also offers potential avenues for therapeutic interventions in diseases characterized by ribosomal dysfunction. As such, NOC4L continues to be a significant focus in molecular and cellular biology, with ongoing studies aimed at unraveling its complex role within the nucleolar framework and its impact on cellular homeostasis.
