Analytical Data
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Gene name
NMUR1
- Application
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Alternative Names
NMUR1; GPR66; Neuromedin-U receptor 1; NMU-R1; G-protein coupled receptor 66; G-protein coupled receptor FM-3
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HB89
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Expression Region
1-426 aa
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AA Sequence
MTPLCLNCSVLPGDLYPGGARNPMACNGSAARGHFDPEDLNLTDEALRLKYLGPQQTELFMPICATYLLIFVVGAVGNGLTCLVILRHKAMRTPTNYYLFSLAVSDLLVLLVGLPLELYEMWHNYPFLLGVGGCYFRTLLFEMVCLASVLNVTALSVERYVAVVHPLQARSMVTRAHVRRVLGAVWGLAMLCSLPNTSLHGIQQLHVPCRGPVPDSAVCMLVRPRALYNMVVQTTALLFFCLPMAIMSVLYLLIGLRLRRERLLLMQEAKGRGSAAARSRYTCRLQQHDRGRRQVTKMLFVLVVVFGICWAPFHADRVMWSVVSQWTDGLHLAFQHVHVISGIFFYLGSAANPVLYSLMSSRFRETFQEALCLGACCHRLRPRHSSHSLSRMTTGSTLCDVGSLGSWVHPLAGNDGPEAQQETDPS
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Molecular Weight
73.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NMUR1 (Neuropeptide FF receptor 1) is a G protein-coupled receptor (GPCR) that plays a significant role in various physiological processes, including pain modulation, inflammation, and neuroendocrine regulation. The interest in NMUR1 has surged due to its potential implications in treating conditions such as chronic pain, obesity, and anxiety disorders. Understanding the structure and function of NMUR1 is crucial for the development of targeted therapies. Research on recombinant NMUR1 proteins focuses on their expression, purification, and characterization, which are essential steps for studying their signaling pathways and interactions with ligands. Advances in protein engineering and expression systems have enabled researchers to produce functional NMUR1 proteins for in-depth pharmacological studies. These studies aim to elucidate the receptor’s role in physiological and pathological conditions, ultimately aiding in the identification of new therapeutic targets. Furthermore, the investigation of NMUR1 antagonists and agonists could lead to novel treatment options, making it a promising area of research in the field of neuropharmacology and drug development.
