Analytical Data
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基因名
SAR1B
- Application
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别名
SAR1B;SARA2;SARB;Small COPII coat GTPase SAR1B
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y6B6
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表达区间
1-198aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MGSMSFIFDW IYSGFSSVLQ FLGLYKKTGK LVFLGLDNAG KTTLLHMLKD DRLGQHVPTL HPTSEELTIA GMTFTTFDLG GHVQARRVWK NYLPAINGIV FLVDCADHER LLESKEELDS LMTDETIANV PILILGNKID RPEAISEERL REMFGLYGQT TGKGSISLKE LNARPLEVFM CSVLKRQGYG EGFRWMAQYI D
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分子量
25 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SAR1B is a key protein involved in the transport of proteins and lipids from the endoplasmic reticulum (ER) to the Golgi apparatus. It is a member of the Sar1 family of small GTPases, which are crucial for the initiation of protein transport via COPII vesicles. Mutations in the SAR1B gene have been linked to various human diseases, particularly a form of congenital disorders of glycosylation known as CDG-IIc. These mutations disrupt the normal functioning of the protein, leading to impaired glycoprotein synthesis and severe clinical manifestations. Research on SAR1B recombinant proteins has gained traction due to its potential implications in understanding the molecular mechanisms underlying these diseases and identifying therapeutic targets. By studying the structure, function, and dynamics of SAR1B, scientists hope to shed light on the role of vesicular transport in health and disease, and develop strategies to mitigate the effects of mutations within this pathway. Additionally, investigating SAR1B activity may provide insights into broader cellular processes, as vesicular transport is fundamental to maintaining cellular homeostasis and intercellular communication. The ongoing research in this field aims to unravel the intricate network of protein trafficking and highlight the significance of SAR1B as a critical component in cellular biology.
