Analytical Data
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Gene name
PANK2
- Application
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Alternative Names
PANK2；C20orf48；Pantothenate kinase 2. mitochondrial
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BZ23
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Expression Region
47-570aa
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AA Sequence
SLSL DGGTVNPPRV REPTGREAFG PSPASSDWLP ARWRNGRGGR PRARLCSGWT AAEEARRNPT LGGLLGRQRL LLRMGGGRLG APMERHGRAS ATSVSSAGEQ AAGDPEGRRQ EPLRRRASSA SVPAVGASAE GTRRDRLGSY SGPTSVSRQR VESLRKKRPL FPWFGLDIGG TLVKLVYFEP KDITAEEEEE EVESLKSIRK YLTSNVAYGS TGIRDVHLEL KDLTLCGRKG NLHFIRFPTH DMPAFIQMGR DKNFSSLHTV FCATGGGAYK FEQDFLTIGD LQLCKLDELD CLIKGILYID SVGFNGRSQC YYFENPADSE KCQKLPFDLK NPYPLLLVNI GSGVSILAVY SKDNYKRVTG TSLGGGTFFG LCCLLTGCTT FEEALEMASR GDSTKVDKLV RDIYGGDYER FGLPGWAVAS SFGNMMSKEK REAVSKEDLA RATLITITNN IGSIARMCAL NENINQVVFV GNFLRINTIA MRLLAYALDY WSKGQLKALF SEHEGYFGAV GALLELLKIP
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Molecular Weight
62.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PANK2, or Pantothenate Kinase 2, is a crucial enzyme involved in the biosynthesis of coenzyme A, which plays a vital role in various metabolic pathways, including fatty acid metabolism and the synthesis of neurotransmitters. Mutations in the PANK2 gene lead to neurodegenerative disorders, particularly infantile neurodegeneration with brain iron accumulation, known as PKAN. The research surrounding PANK2 recombinant protein aims to better understand its structure, function, and the implications of its mutations in disease. By producing and characterizing the recombinant form of PANK2, scientists can explore the enzyme's kinetic properties, interaction with other proteins, and the impact of specific mutations on its activity. This research is vital for developing potential therapeutic strategies for PKAN and related metabolic disorders. Furthermore, insights gained from PANK2 studies may provide broader implications for understanding the role of CoA in cellular metabolism and neurodegeneration, paving the way for novel interventions in metabolic diseases. The study of PANK2 recombinant protein thus represents a significant avenue of investigation with potential clinical relevance, particularly in the context of genetic disorders and metabolic dysfunctions.
