Analytical Data
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基因名
NMNAT2
- Application
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别名
C1orf15; KIAA0479; MGC2756; NaMN adenylyltransferase 2; Nicotinamide mononucleotide adenylyltransferase 2; Nicotinamide nucleotide adenylyltransferase 2; Nicotinate-nucleotide adenylyltransferase 2; NMN adenylyltransferase 2; NMNA2_HUMAN; NMNAT 2; Nmnat2; PNAT 2; PNAT2; Pyridine nucleotide adenylyltransferase 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9BZQ4
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表达区间
1-307 aa
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氨基酸序列
MTETTKTHVI LLACGSFNPI TKGHIQMFER ARDYLHKTGR FIVIGGIVSP VHDSYGKQGL VSSRHRLIMC QLAVQNSDWI RVDPWECYQD TWQTTCSVLE HHRDLMKRVT GCILSNVNTP SMTPVIGQPQ NETPQPIYQN SNVATKPTAA KILGKVGESL SRICCVRPPV ERFTFVDENA NLGTVMRYEE IELRILLLCG SDLLESFCIP GLWNEADMEV IVGDFGIVVV PRDAADTDRI MNHSSILRKY KNNIMVVKDD INHPMSVVSS TKSRLALQHG DGHVVDYLSQ PVIDYILKSQ LYINASG
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分子量
34.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Nicotinamide mononucleotide adenyltransferase 2 (NMNAT2) is a crucial enzyme involved in the biosynthesis of nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for various cellular processes, including energy metabolism, DNA repair, and cell signaling. Recent studies have highlighted the importance of NMNAT2 in neuroprotection, with particular attention given to its role in preventing neuronal cell death in neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. The reduction of NAD+ levels is often observed in aging and various pathological conditions, emphasizing the potential therapeutic benefits of NMNAT2. Recombinant NMNAT2 protein has become a focal point of research due to its ability to restore NAD+ levels and improve cellular resilience against stress-induced damage. The development of recombinant NMNAT2 not only aids in understanding its structural and functional characteristics but also facilitates investigations into its potential as a therapeutic target. Studies employing advanced techniques, such as X-ray crystallography and cryo-electron microscopy, aim to elucidate the enzyme's three-dimensional structure and catalytic mechanisms. Furthermore, exploring the effects of NMNAT2 on neuronal health and its interactions with other biomolecules can provide valuable insights into its role in maintaining cellular homeostasis. Therefore, research on recombinant NMNAT2 protein holds promise for advancing our understanding of NAD+ metabolism and developing innovative strategies for combating age-related diseases and promoting neural health.
