Analytical Data
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Gene name
SAP18
- Application
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Alternative Names
SAP18;Histone deacetylase complex subunit SAP18
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00422
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Expression Region
2-153aa
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AA Sequence
AVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM TLQSQKFQIG DYLDIAITPP NRAPPPSGRM RPY
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SAP18 is a crucial protein involved in the regulation of gene expression and chromatin remodeling. It plays a significant role in various cellular processes, including transcription regulation, DNA repair, and cell differentiation. Research on SAP18 has gained attention due to its association with several diseases, particularly cancer, where abnormalities in its expression and function may influence tumor progression and resistance to therapies. Through its interaction with other proteins and its involvement in the assembly of transcriptional complexes, SAP18 impacts the epigenetic landscape of the cell. The study of its structure and function can provide valuable insights into the molecular mechanisms underlying gene regulation and the potential therapeutic targets for diseases linked to dysregulation of gene expression. Recent advances in protein purification techniques and structural biology have paved the way for more detailed investigations into SAP18’s role and its potential as a biomarker or therapeutic target. Understanding the reorganization of SAP18 and its complexes is essential for elucidating its functional capabilities and implications in health and disease.
