Analytical Data
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Gene name
NECAB1
- Application
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Alternative Names
EF-hand calcium-binding protein 1; EFCBP1; N-terminal EF-hand calcium-binding protein 1; NECA1_HUMAN; Necab1; neuronal calcium binding protein; Neuronal calcium-binding protein 1; STIP-1; synaptotagmin interacting protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N987
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Expression Region
1-351 aa
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AA Sequence
MEDSQETSPS SNNSSEELSS ALHLSKGMSI FLDILRRADK NDDGKLSFEE FKAYFADGVL SGEELHELFH TIDTHNTNNL DTEELCEYFS QHLGEYENVL AALEDLNLSI LKAMGKTKKD YQEASNLEQF VTRFLLKETL NQLQSLQNSL ECAMETTEEQ TRQERQGPAK PEVLSIQWPG KRSSRRVQRH NSFSPNSPQF NVSGPGLLEE DNQWMTQINR LQKLIDRLEK KDLKLEPPEE EIIEGNTKSH IMLVQRQMSV IEEDLEEFQL ALKHYVESAS SQSGCLRISI QKLSNESRYM IYEFWENSSV WNSHLQTNYS KTFQRSNVDF LETPELTSTM LVPASWWILN N
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Molecular Weight
40.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NECAB1 (NEural CAreful with AB1) is a member of the NECAB family, which is involved in various cellular processes, including signal transduction and cytoskeletal dynamics. Research into NECAB1 has gained momentum due to its potential role in neurological health and disease. Observations suggest that NECAB1 may act as a modulator of calcium signaling and interact with key proteins involved in neuronal development and function. The understanding of NECAB1’s structure and function could provide insights into its regulatory mechanisms and its implications in neurodegenerative disorders. Investigations have indicated that alterations in NECAB1 expression may be linked to pathologies such as Alzheimer's disease and other cognitive impairments. Therefore, the development and characterization of recombinant NECAB1 protein are crucial for elucidating its biological roles and therapeutic potential. By leveraging techniques such as molecular cloning and protein expression, researchers aim to produce functional NECAB1 for further biochemical and cellular studies. This research has significant implications for understanding the molecular basis of neurological conditions and could pave the way for novel therapeutic strategies targeting NECAB1-related pathways.
