Cat: PA2000-1096

Recombinant Human C22orf28 Protein,His

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Analytical Data

  • Gene name

    C22orf28

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    C22orf28;C22orf28;RNA-splicing ligase RtcB homolog

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    Q9Y3I0

  • Expression Region

    1-505aa

  • AA Sequence

    MSRSYNDELQ FLEKINKNCW RIKKGFVPNM QVEGVFYVND ALEKLMFEEL RNACRGGGVG GFLPAMKQIG NVAALPGIVH RSIGLPDVHS GYGFAIGNMA AFDMNDPEAV VSPGGVGFDI NCGVRLLRTN LDESDVQPVK EQLAQAMFDH IPVGVGSKGV IPMNAKDLEE ALEMGVDWSL REGYAWAEDK EHCEEYGRML QADPNKVSAR AKKRGLPQLG TLGAGNHYAE IQVVDEIFNE YAAKKMGIDH KGQVCVMIHS GSRGLGHQVA TDALVAMEKA MKRDKIIVND RQLACARIAS PEGQDYLKGM AAAGNYAWVN RSSMTFLTRQ AFAKVFNTTP DDLDLHVIYD VSHNIAKVEQ HVVDGKERTL LVHRKGSTRA FPPHHPLIAV DYQLTGQPVL IGGTMGTCSY VLTGTEQGMT ETFGTTCHGA GRALSRAKSR RNLDFQDVLD KLADMGIAIR VASPKLVMEE APESYKNVTD VVNTCHDAGI SKKAIKLRPI AVIKG

  • Molecular Weight

    55.2 kDa

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

C22orf28, also known as Interleukin-18-binding protein (IL-18BP), is a gene located on chromosome 22 that has garnered attention due to its role in modulating immune responses. It encodes a protein that binds to interleukin-18 (IL-18), a pro-inflammatory cytokine involved in the regulation of various immune functions, including the activation of T cells and natural killer (NK) cells. By sequestering IL-18, C22orf28 plays a pivotal role in controlling inflammation, making it a critical factor in autoimmune diseases and chronic inflammatory conditions. The study of C22orf28 recombinant protein is significant for understanding the mechanisms of immune regulation and developing potential therapeutic strategies. Research has demonstrated that C22orf28 can affect the signaling pathways involved in various diseases, such as rheumatoid arthritis and certain cancers. The recombinant protein can be utilized in experimental settings to elucidate its interactions with IL-18 and other cytokines, thereby providing insight into its biological functions. Furthermore, investigating the structure and dynamics of C22orf28 could reveal key features that might be exploited for drug design or therapeutic interventions. Overall, the study of C22orf28 recombinant protein offers a promising avenue for advancing our understanding of immune modulation, paving the way for novel treatments in inflammatory and autoimmune disorders.

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