Analytical Data
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Gene name
FZD9
- Application
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Alternative Names
FZD9；FZD3；Frizzled-9
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00144
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Expression Region
1-591aa
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AA Sequence
MAVAPLRGALLLWQLLAAGGAALEIGRFDPERGRGAAPCQAVEIPMCRGIGYNLTRMPNLLGHTSQGEAAAELAEFAPLVQYGCHSHLRFFLCSLYAPMCTDQVSTPIPACRPMCEQARLRCAPIMEQFNFGWPDSLDCARLPTRNDPHALCMEAPENATAGPAEPHKGLGMLPVAPRPARPPGDLGPGAGGSGTCENPEKFQYVEKSRSCAPRCGPGVEVFWSRRDKDFALVWMAVWSALCFFSTAFTVLTFLLEPHRFQYPERPIIFLSMCYNVYSLAFLIRAVAGAQSVACDQEAGALYVIQEGLENTGCTLVFLLLYYFGMASSLWWVVLTLTWFLAAGKKWGHEAIEAHGSYFHMAAWGLPALKTIVILTLRKVAGDELTGLCYVASTDAAALTGFVLVPLSGYLVLGSSFLLTGFVALFHIRKIMKTGGTNTEKLEKLMVKIGVFSILYTVPATCVIVCYVYERLNMDFWRLRATEQPCAAAAGPGGRRDCSLPGGSVPTVAVFMLKIFMSLVVGITSGVWVWSSKTFQTWQSLCYRKIAAGRARAKACRAPGSYGRGTHCHYKAPTVVLHMTKTDPSLENPTHL
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Molecular Weight
64.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FZD9, or Frizzled-9, is a member of the Frizzled family of proteins, which serve as receptors for Wnt signaling pathways, crucial for numerous biological processes, including cell proliferation, differentiation, and tissue homeostasis. Understanding the role of FZD9 in these pathways is critical, as dysregulation of Wnt signaling is implicated in various diseases, including cancer. Research into the recombinant production of FZD9 protein aims to provide insights into its structure-function relationships and its interactions with Wnt ligands and other signaling molecules. By generating FZD9 in a recombinant system, such as yeast or mammalian cells, scientists can study its biochemical properties, investigate its receptor mechanisms, and explore its potential as a therapeutic target. Additionally, recombinant FZD9 can be utilized for high-throughput screening assays to identify novel inhibitors or modulators of Wnt signaling. The comprehensive characterization of this receptor protein will enhance our understanding of the molecular underpinnings underlying developmental processes and disease pathology, thereby paving the way for potential therapeutic strategies in conditions associated with Wnt signaling dysregulation.
