Analytical Data
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Gene name
RGS21
- Application
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Alternative Names
RGS21;Regulator of G-Protein signaling 21
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q2M5E4
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Expression Region
1-152aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSH MPVKCC FYRSPTAETM TWSENMDTLL ANQAGLDAFR IFLKSEFSEE NVEFWLACED FKKTKNADKI ASKAKMIYSE FIEADAPKEI NIDFGTRDLI SKNIAEPTLK CFDEAQKLIY CLMAKDSFPR FLKSEIYKKL VNSQQVPNHK KWLPFL
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Molecular Weight
20 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RGS21 (Regulator of G-protein signaling 21) is a member of the RGS protein family, which plays a crucial role in modulating G-protein-coupled receptor (GPCR) signaling pathways. GPCRs are vital for various physiological processes and are significant targets for drug development due to their involvement in numerous diseases. RGS proteins, including RGS21, act as facilitators that accelerate the GTPase activity of G-proteins, thereby influencing signal transduction and maintaining cellular homeostasis. Research on RGS21 has gained momentum due to its unique structural features and its potential role in regulating specific GPCRs associated with neurological functions and cardiovascular health. Elevated expression levels of RGS21 have been implicated in certain pathological conditions, such as heart failure and neurodegenerative diseases, making it a potential therapeutic target. Understanding the structure-function relationship of RGS21 through recombinant protein studies can shed light on its mechanisms of action and interaction with GPCRs, ultimately guiding the development of innovative pharmacological strategies. This research not only enhances our comprehension of GPCR signaling but also opens avenues for targeted therapies that can modulate these pathways with higher specificity and fewer side effects.
