Analytical Data
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Gene name
RGS2
- Application
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Alternative Names
RGS2;G0S8;Regulator of G-Protein signaling 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P41220
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Expression Region
1-211aa
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AA Sequence
MQSAMFLAVQHDCRPMDKSAGSGHKSEEKREKMKRTLLKDWKTRLSYFLQNSSTPGKPKTGKKSKQQAFIKPSPEEAQLWSEAFDELLASKYGLAAFRAFLKSEFCEENIEFWLACEDFKKTKSPQKLSSKARKIYTDFIEKEAPKEINIDFQTKTLIAQNIQEATSGCFTTAQKRVYSLMENNSYPRFLESEFYQDLCKKPQITTEPHAT
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Molecular Weight
40.4kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RGS2 (Regulator of G protein signaling 2) is a critical member of the RGS family that plays a vital role in modulating G protein-coupled receptor (GPCR) signaling pathways. These pathways are essential for numerous physiological processes, including hormone signaling, neurotransmission, and immune responses. Dysregulation of RGS2 has been implicated in various pathological conditions such as hypertension, anxiety disorders, and heart failure, highlighting its potential as a therapeutic target. Research on RGS2 often involves the production of recombinant RGS2 protein, which allows scientists to study its structure, function, and interactions in controlled experimental settings. Recombinant RGS2 can be expressed in various systems, such as bacteria or mammalian cells, providing insights into its biochemical properties and role in cellular signaling. Understanding the molecular mechanisms by which RGS2 modulates G protein signaling is crucial, as it may lead to the development of novel pharmacological agents that can selectively modulate these pathways, offering new therapeutic approaches for diseases associated with RGS2 dysregulation. Additionally, studies on RGS2 reconstitution in cellular models can illuminate its potential roles in drug efficacy and safety, thus broadening the scope of cardiovascular and psychiatric treatments. Overall, the research surrounding RGS2 recombinant protein is a promising field that may yield significant advancements in understanding and treating various diseases linked to GPCR signaling.
