Analytical Data
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基因名
RASSF1A
- Application
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别名
RASSF1;RDA32;Ras association domain-containing Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9NS23
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表达区间
2-344aa
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氨基酸序列
SGEPELIEL RELAPAGRAG KGRTRLERAN ALRIARGTAC NPTRQLVPGR GHRFQPAGPA THTWCDLCGD FIWGVVRKGL QCARLSADCK FTCHYRCRAL VCLDCCGPRD LGWEPAVERD TNVDEPVEWE TPDLSQAEIE QKIKEYNAQI NSNLFMSLNK DGSYTGFIKV QLKLVRPVSV PSSKKPPSLQ DARRGPGRGT SVRRRTSFYL PKDAVKHLHV LSRTRAREVI EALLRKFLVV DDPRKFALFE RAERHGQVYL RKLLDDEQPL RLRLLAGPSD KALSFVLKEN DSGEVNWDAF SMPELHNFLR ILQREEEEHL RQILQKYSYC RQKIQEALHA CPLG
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RASSF1A (Ras Association Domain Family 1 Isoform A) is a crucial tumor suppressor protein that plays a significant role in various cellular processes, including cell cycle regulation, apoptosis, and microtubule stabilization. Research has shown that RASSF1A is frequently epigenetically silenced or lost in various cancers, implicating its status as a potential biomarker and therapeutic target. The protein is involved in signaling pathways that regulate cell growth and death, particularly in response to Ras and other oncogenic signals. Its ability to interact with other key proteins like MST1/2 kinases in the Hippo signaling pathway highlights its importance in maintaining normal cellular function and preventing uncontrolled proliferation. Recent studies have focused on understanding the mechanisms regulating RASSF1A expression, exploring its potential as a prognostic indicator, and investigating the therapeutic implications of restoring its function in cancer treatment. This research underscores the pressing need to further elucidate the biology of RASSF1A, how its dysregulation contributes to tumorigenesis, and its viability as a target for novel cancer therapies.
