Analytical Data
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基因名
RAPSN
- Application
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别名
RAPSN;RNF205;43 kDa receptor-associated Protein of the synapse
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q13702
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表达区间
2-412aa
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氨基酸序列
GQDQTKQQI EKGLQLYQSN QTEKALQVWT KVLEKSSDLM GRFRVLGCLV TAHSEMGRYK EMLKFAVVQI DTARELEDAD FLLESYLNLA RSNEKLCEFH KTISYCKTCL GLPGTRAGAQ LGGQVSLSMG NAFLGLSVFQ KALESFEKAL RYAHNNDDAM LECRVCCSLG SFYAQVKDYE KALFFPCKAA ELVNNYGKGW SLKYRAMSQY HMAVAYRLLG RLGSAMECCE ESMKIALQHG DRPLQALCLL CFADIHRSRG DLETAFPRYD SAMSIMTEIG NRLGQVQALL GVAKCWVARK ALDKALDAIE RAQDLAEEVG NKLSQLKLHC LSESIYRSKG LQRELRAHVV RFHECVEETE LYCGLCGESI GEKNSRLQAL PCSHIFHLRC LQNNGTRSCP NCRRSSMKPG FV
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAPSN (Receptor-Associated Protein of the Synapse, also known as rapsyn) is a crucial scaffolding protein involved in the clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction and in the central nervous system. The study of RAPSN has gained significant attention due to its essential role in synaptic transmission and neurotransmission processes. Mutations and dysregulation of RAPSN have been implicated in congenital myasthenic syndromes, a group of inherited disorders characterized by weakness and fatigability of voluntary muscles, highlighting its importance in muscle function and neuromuscular disorders. Furthermore, RAPSN's interactions with various signaling molecules and receptors suggest that it may also play a role in synaptic plasticity, learning, and memory, thus making it a potential target for therapeutic interventions in neurodegenerative diseases and cognitive disorders. Research into the structural and functional properties of RAPSN, alongside its role in receptor clustering and signaling, could unveil new insights into synaptic integrity and the molecular mechanisms underpinning neuromuscular transmission. As a result, the recombinant expression of RAPSN in various model systems is being explored to elucidate its functional dynamics, interactions with nAChRs, and its potential role in developing targeted treatments for related disorders. These studies aim to advance our understanding of synaptic formation and maintenance, thereby paving the way for novel approaches in treating conditions associated with synaptic dysfunction.
