Analytical Data
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基因名
MYST1
- Application
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别名
Histone acetyltransferase KAT8; Histone acetyltransferase MYST1; hMOF; K(lysine) acetyltransferase 8; KAT 8; Lysine acetyltransferase 8; MOF; MOZ; MOZ. YBF2/SAS3. SAS2 and TIP60 protein 1; MYST 1; MYST histone acetyltransferase 1; myst protein 1; MYST-1; MYST1; MYST1_HUMAN; Ortholog of Drosophila males absent on the first (MOF); Probable histone acetyltransferase MYST1; SAS2 and TIP60 protein 1; SAS2; SAS3; TIP60 protein 1; YBF2; YBF2/SAS3; ZC2HC8
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H7Z6
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表达区间
2-458 aa
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氨基酸序列
AAQGAAAAV AAGTSGVAGE GEPGPGENAA AEGTAPSPGR VSPPTPARGE PEVTVEIGET YLCRRPDSTW HSAEVIQSRV NDQEGREEFY VHYVGFNRRL DEWVDKNRLA LTKTVKDAVQ KNSEKYLSEL AEQPERKITR NQKRKHDEIN HVQKTYAEMD PTTAALEKEH EAITKVKYVD KIHIGNYEID AWYFSPFPED YGKQPKLWLC EYCLKYMKYE KSYRFHLGQC QWRQPPGKEI YRKSNISVYE VDGKDHKIYC QNLCLLAKLF LDHKTLYFDV EPFVFYILTE VDRQGAHIVG YFSKEKESPD GNNVACILTL PPYQRRGYGK FLIAFSYELS KLESTVGSPE KPLSDLGKLS YRSYWSWVLL EILRDFRGTL SIKDLSQMTS ITQNDIISTL QSLNMVKYWK GQHVICVTPK LVEEHLKSAQ YKKPPITVDS VCLKWAPPKH KQVKLSKK
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分子量
52.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MYST1, a member of the MYST family of histone acetyltransferases, plays a crucial role in various cellular processes, including chromatin remodeling, gene expression regulation, and DNA repair. The name MYST is derived from the first letters of the four founding members of the family: MOZ, Ybf2, Sas2, and Tip60. MYST1 is particularly significant in the context of development and differentiation, as it is involved in regulating the transcription of genes essential for both processes. Dysregulation of MYST1 has been linked to several diseases, including cancer and developmental disorders, highlighting its importance in maintaining cellular homeostasis. The recombinant expression of MYST1 provides a valuable tool for studying its enzymatic activities, interactions with other proteins, and the downstream effects of its acetylation activity on target substrates. Understanding the structure and function of MYST1 through recombinant protein studies can offer insights into its biological roles and mechanisms, potentially leading to new therapeutic strategies for conditions associated with its dysfunction. Researchers have employed various expression systems to produce MYST1, allowing for in-depth characterization of its biochemical properties and functional assays. This research not only enhances our understanding of MYST1's role in cellular metabolism but also contributes to the broader field of epigenetics, where the modulation of histone acetylation is critical for regulating gene expression and cellular responses to environmental cues.
