Analytical Data
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基因名
RAMP3
- Application
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别名
RAMP3;Receptor activity-modifying Protein 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O60896
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表达区间
24-118aa
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氨基酸序列
MGSSHHHHHH SSGLVPRGSH MRAGGCNETG MLERLPLCGK AFADMMGKVD VWKWCNLSEF IVYYESFTNC TEMEANVVGC YWPNPLAQGF ITGIHRQFFS NCTVDRVHLE DPPDEV
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分子量
13 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RAMP3 (Receptor Activity-Modifying Protein 3) is a critical member of the RAMP family, which plays a significant role in the modulation of G protein-coupled receptors (GPCRs), particularly the calcitonin gene-related peptide receptor (CGRP-R). Research on RAMP3 has gained attention due to its involvement in various physiological processes, including pain perception, cardiovascular regulation, and neuroprotection. The RAMP proteins interact with GPCRs, influencing their trafficking, signaling, and ligand specificity, which can have profound implications in the context of drug development. Understanding RAMP3's structure and function, especially in relation to its partner receptors, could lead to novel therapeutic strategies for conditions like migraine, where CGRP signaling is a key factor. Moreover, investigating RAMP3’s interactions with different receptor systems can provide insights into its potential roles in various pathophysiological states. Recent advances in recombinant protein technology have made it possible to express and purify RAMP3, allowing for detailed studies of its biochemical properties and interactions. This research has the potential to unravel the complexities of GPCR signaling and highlight RAMP3 as a promising target for pharmacological intervention.
