Analytical Data
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Gene name
MRPS5
- Application
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Alternative Names
28S ribosomal protein S5; Mitochondrial 28S ribosomal protein S5; mitochondrial; mitochondrial ribosomal protein S5; MRP S5; MRP-S5; Mrps5; RT05_HUMAN; S5mt
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P82675
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Expression Region
1-430 aa
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AA Sequence
MATAVRAVGC LPVLCSGTAG HLLGRQCSLN TLPAASILAW KSVLGNGHLS SLGTRDTHPY ASLSRALQTQ CCISSPSHLM SQQYRPYSFF TKLTADELWK GALAETGAGA KKGRGKRTKK KKRKDLNRGQ IIGEGRYGFL WPGLNVPLMK NGAVQTIAQR SKEEQEKVEA DMIQQREEWD RKKKMKVKRE RGWSGNSWGG ISLGPPDPGP CGETYEDFDT RILEVRNVFT MTAKEGRKKS IRVLVAVGNG KGAAGFSIGK ATDRMDAFRK AKNRAVHHLH YIERYEDHTI FHDISLRFKR THIKMKKQPK GYGLRCHRAI ITICRLIGIK DMYAKVSGSI NMLSLTQGLF RGLSRQETHQ QLADKKGLHV VEIREECGPL PIVVASPRGP LRKDPEPEDE VPDVKLDWED VKTAQGMKRS VWSNLKRAAT
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Molecular Weight
48.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRPS5, a mitochondrial ribosomal protein, plays a crucial role in mitochondrial protein synthesis, which is essential for cellular energy metabolism and overall cellular functions. Its significance has gained attention in recent years due to emerging evidence linking mitochondrial dysfunction to various diseases, including neurodegenerative disorders, metabolic syndromes, and certain cancers. Research has shown that MRPS5 participates in the assembly of the mitochondrial ribosome, influencing the translation of mitochondrial genes encoded by the mitochondrial genome. Mutations or dysregulation of MRPS5 can disrupt mitochondrial function, leading to compromised ATP production and increased oxidative stress. Consequently, investigating the recombinant protein MRPS5 has become important for understanding its structural and functional properties, as well as its potential as a therapeutic target. Studies on MRPS5 are focusing on its role in mitochondrial translation, interactions with other mitochondrial proteins, and its impact on cell viability and apoptosis. The development of recombinant MRPS5 not only aids in elucidating its function but also enhances our understanding of mitochondrial diseases and may pave the way for innovative treatment strategies. Understanding the molecular mechanisms involved with MRPS5 can unlock new avenues for therapeutic intervention in conditions where mitochondrial dysfunction is a contributing factor, thereby highlighting the critical need for continued research in this area.
