Analytical Data
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Gene name
Atp5f1c
- Application
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Alternative Names
ATP synthase F1 subunit gamma (F-ATPase gamma subunit)
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P36542
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Expression Region
26-298aa
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AA Sequence
ATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAERELKPARIYGLGSLALYEKADIKGPEDKKKHLLIGVSSDRGLCGAIHSSIAKQMKSEVATLTAAGKEVMLVGIGDKIRGILYRTHSDQFLVAFKEVGRKPPTFGDASVIALELLNSGYEFDEGSIIFNKFRSVISYKTEEKPIFSLNTVASADSMSIYDDIDADVLQNYQEYNLANIIYYSLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALD
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Molecular Weight
37.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ATP5F1C, also known as ATP synthase F1 subunit gamma, is a crucial component of the mitochondrial ATP synthase complex, which plays a key role in energy production through oxidative phosphorylation. Research on ATP5F1C is significant because it contributes to our understanding of mitochondrial function and its implications in various metabolic disorders. This subunit is involved in the catalytic activity of ATP synthesis, and any alterations in its expression or function can lead to energy metabolism abnormalities associated with diseases such as neurodegenerative disorders, cardiovascular diseases, and certain types of cancer. The study of recombinant ATP5F1C allows for the detailed investigation of its biochemical properties, interactions with other subunits, and its regulatory mechanisms within the ATP synthase complex. By producing and characterizing recombinant ATP5F1C, researchers aim to unveil its structural and functional dynamics, which could reveal potential therapeutic targets for conditions arising from mitochondrial dysfunction. Additionally, understanding the role of ATP5F1C in cellular bioenergetics can provide insights into the evolution of mitochondrial function and its adaptation in different physiological contexts. As a result, ongoing research on recombinant ATP5F1C is vital for advancing our knowledge of mitochondrial biology and developing strategies to combat related diseases.
