Analytical Data
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Gene name
PSMB7
- Application
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Alternative Names
PSMB7;Z;Proteasome subunit beta type-7
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99436
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Expression Region
44-277aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MTTIAGVVYK DGIVLGADTR ATEGMVVADK NCSKIHFISP NIYCCGAGTA ADTDMTTQLI SSNLELHSLS TGRLPRVVTA NRMLKQMLFR YQGYIGAALV LGGVDVTGPH LYSIYPHGST DKLPYVTMGS GSLAAMAVFE DKFRPDMEEE EAKNLVSEAI AAGIFNDLGS GSNIDLCVIS KNKLDFLRPY TVPNKKGTRL GRYRCEKGTT AVLTEKITPL EIEVLEETVQ TMDTS
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Molecular Weight
28 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PSMB7, a component of the 20S proteasome, plays a crucial role in the ubiquitin-proteasome system, which is essential for protein degradation and cellular homeostasis. It is responsible for processing and degrading misfolded and damaged proteins, thus regulating various cellular functions, including the cell cycle, apoptosis, and antigen presentation. Abnormalities in PSMB7 expression or function have been implicated in several diseases, including cancer and neurodegenerative disorders, highlighting its potential as a therapeutic target. Recent studies have focused on the reconstitution of PSMB7 as a recombinant protein to better understand its structure-function relationships and interactions with other proteasome components. Such research aims to elucidate the mechanisms underlying proteasomal degradation and its regulatory role in cellular processes. By utilizing recombinant technology, researchers are able to produce large quantities of PSMB7, facilitating biochemical assays, crystallography, and structure-based drug design. This approach has significant implications for developing novel treatments aimed at restoring proteasome function in diseases associated with proteostasis imbalances, making PSMB7 a pivotal protein in the field of cellular biology and therapeutic development.
