Analytical Data
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Gene name
UPP2
- Application
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Alternative Names
UPP2；Uridine phosphorylase 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O95045
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Expression Region
1-317aa
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AA Sequence
MASVIPASNR SMRSDRNTYV GKRFVHVKNP YLDLMDEDIL YHLDLGTKTH NLPAMFGDVK FVCVGGSPNR MKAFALFMHK ELGFEEAEED IKDICAGTDR YCMYKTGPVL AISHGMGIPS ISIMLHELIK LLHHARCCDV TIIRIGTSGG IGIAPGTVVI TDIAVDSFFK PRFEQVILDN IVTRSTELDK ELSEELFNCS KEIPNFPTLV GHTMCTYDFY EGQGRLDGAL CSFSREKKLD YLKRAFKAGV RNIEMESTVF AAMCGLCGLK AAVVCVTLLD RLDCDQINLP HDVLVEYQQR PQLLISNFIR RRLGLCD
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Molecular Weight
35.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
UPP2, or Uridine Phosphate Pyrophosphatase 2, is an enzyme involved in nucleotide metabolism, particularly in the dephosphorylation of uridine nucleotides. The study of UPP2 is gaining attention due to its potential roles in various biological processes and its implications in human diseases. Research has shown that UPP2 may play a key role in regulating nucleotide pools within cells, which is crucial for DNA and RNA synthesis, energy metabolism, and signaling pathways. Furthermore, aberrations in UPP2 activity have been linked to certain pathological conditions, including cancer and metabolic disorders, suggesting that it could serve as a therapeutic target. Understanding the structural and functional properties of UPP2 is essential for elucidating its biological significance and for developing inhibitors that could modulate its activity. Recent advancements in recombinant protein technology have facilitated the production and purification of UPP2, allowing for detailed biochemical and structural studies. These investigations aim to uncover the mechanism of action of UPP2 and its interactions with other cellular components, providing insights that could lead to novel therapeutic strategies. As research progresses, the potential of UPP2 in drug development, particularly in targeting specific metabolic pathways in diseases, continues to be a promising area of exploration.
