Analytical Data
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Gene name
PSMA4
- Application
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Alternative Names
PSMA4;HC9;PSC9;Proteasome subunit alpha type-4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P25789
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Expression Region
1-261aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MGSHMSLQYG AEETPLAGSY GAADSFPKDF GYGVEEEEEE AAAAGGGVGA GAGGGCGPGG ADSSKPRILL MGLRRSGKSS IQKVVFHKMS PNETLFLEST NKIYKDDISN SSFVNFQIWD FPGQMDFFDP TFDYEMIFRG TGALIYVIDA QDDYMEALTR LHITVSKAYK VNPDMNFEVF IHKVDGLSDD HKIETQRDIH QRANDDLADA GLEKLHLSFY LTSIYDHSIF EAFSKVVQKL IPQLPTLENL LNIFISNSGI EKAFLFDVVS KIYIATDSSP VDMQSYELCC DMIDVVIDVS CIYGLKEDGS GSAYDKESMA IIKLNNTTVL YLKEVTKFLA LVCILREESF ERKGLIDYNF HCFRKAIHEV FEVGVTSHRS CGHQTSASSL KALTHNGTPR NAI
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Molecular Weight
32 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PSMA4, a component of the 26S proteasome, plays a critical role in the ubiquitin-proteasome pathway, which is essential for protein degradation and turnover in cells. Research on PSMA4 has gained considerable attention due to its involvement in various cellular processes, including cell cycle regulation, apoptosis, and responses to stress. Dysregulation of PSMA4 has been implicated in several diseases, including cancer, neurodegenerative disorders, and inflammatory conditions. Studies have shown that PSMA4 is not only important for maintaining protein homeostasis but also influences the immune response and the processing of antigens. Consequently, understanding the structure and function of PSMA4, along with its potential as a therapeutic target, has become a significant focus in biomedical research. Recent advancements in recombinant protein technology have facilitated the production of PSMA4 for detailed studies, allowing researchers to investigate its enzymatic activity, regulatory mechanisms, and interactions with other proteins. This research not only sheds light on the fundamental biology of PSMA4 but also opens new avenues for developing targeted therapies that could mitigate the effects of diseases linked to proteasome dysfunction. As a result, PSMA4 stands at the intersection of cell biology and therapeutic innovation, making it a promising candidate for future research aimed at understanding and treating complex diseases.
