Analytical Data
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Gene name
MRPL40
- Application
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Alternative Names
MRPL40; NLVCF; URIM; 39S ribosomal protein L40; mitochondrial; L40mt; MRP-L40; Mitochondrial large ribosomal subunit protein mL40; Nuclear localization signal-containing protein deleted in velocardiofacial syndrome; Up-regulated in metastasis
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NQ50
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Expression Region
47-206 aa
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AA Sequence
SEPL RKKKKVDPKK DQEAKERLKR KIRKLEKATQ ELIPIEDFIT PLKFLDKARE RPQVELTFEE TERRALLLKK WSLYKQQERK MERDTIRAML EAQQEALEEL QLESPKLHAE AIKRDPNLFP FEKEGPHYTP PIPNYQPPEG RYNDITKVYT QVEFKR
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Molecular Weight
24.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRPL40, a mitochondrial ribosomal protein, plays a crucial role in mitochondrial protein synthesis and is essential for maintaining mitochondrial function and cellular energy metabolism. Research into MRPL40 has gained momentum due to its potential implications in various diseases, particularly those associated with mitochondrial dysfunction, including neurodegenerative disorders and certain types of cancer. Mitochondria are vital organelles that generate ATP through oxidative phosphorylation, and their dysfunction can lead to impaired energy production and increased oxidative stress. Studies have indicated that alterations in mitochondrial ribosomal proteins, such as MRPL40, can disrupt mitochondrial translation and contribute to disease pathology. Additionally, MRPL40 has been implicated in the regulation of apoptotic pathways, further underscoring its significance in cellular health. As researchers continue to explore the molecular mechanisms underlying MRPL40's functions, understanding its role in mitochondrial dynamics and cellular signaling pathways could pave the way for novel therapeutic approaches aimed at mitigating the effects of mitochondrial-related diseases. The recombinant expression of MRPL40 enables detailed studies of its structure and function, facilitating investigations into its interactions with other mitochondrial components and its potential as a biomarker for disease states. This ongoing research holds promise for advancing our knowledge of mitochondrial biology and developing targeted strategies for intervention in mitochondrial-related pathologies.
