Analytical Data
-
Gene name
PSMA5
- Application
-
Alternative Names
PSMA5;Proteasome subunit alpha type-5
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P28066
-
Expression Region
1-241aa
-
AA Sequence
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMFLT RSEYDRGVNT FSPEGRLFQV EYAIEAIKLG STAIGIQTSE GVCLAVEKRI TSPLMEPSSI EKIVEIDAHI GCAMSGLIAD AKTLIDKARV ETQNHWFTYN ETMTVESVTQ AVSNLALQFG EEDADPGAMS RPFGVALLFG GVDEKGPQLF HMDPSGTFVQ CDARAIGSAS EGAQSSLQEV YHKSMTLKEA IKSSLIILKQ VMEEKLNATN IELATVQPGQ NFHMFTKEEL EEVIKDI
-
Molecular Weight
31 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PSMA5 (Proteasome Subunit Alpha 5) is a crucial component of the 26S proteasome, an essential multi-subunit proteolytic complex responsible for degrading ubiquitinated proteins in eukaryotic cells. This protein plays a vital role in regulating various cellular processes, including the cell cycle, apoptosis, and immune response, by maintaining protein homeostasis and modulating the turnover of key regulatory proteins. Dysregulation of proteasome activity, often linked to cancer and neurodegenerative diseases, highlights the significance of PSMA5 in pathology. Recent studies suggest that PSMA5 not only contributes to proteasome assembly and function but is also involved in intracellular signaling pathways. Furthermore, as researchers explore the potential of targeting the proteasome for therapeutic interventions, PSMA5 has emerged as a promising candidate for drug development. Enhanced understanding of PSMA5’s structure, function, and interactions can provide insights into its role in disease mechanisms and the development of novel treatment strategies, making it a subject of increasing interest in both basic and translational research.
