Analytical Data
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Gene name
MRPL39
- Application
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Alternative Names
MRPL39; C21orf92; MRPL5; RPML5; MSTP003; PRED22; 39S ribosomal protein L39; mitochondrial; L39mt; MRP-L39; 39S ribosomal protein L5; mitochondrial; L5mt; MRP-L5; Mitochondrial large ribosomal subunit protein mL39
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NYK5
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Expression Region
1-338 aa
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AA Sequence
MEALAMGSRA LRLWLVAPGG GIKWRFIATS SASQLSPTEL TEMRNDLFNK EKARQLSLTP RTEKIEVKHV GKTDPGTVFV MNKNISTPYS CAMHLSEWYC RKSILALVDG QPWDMYKPLT KSCEIKFLTF KDCDPGEVNK AYWRSCAMMM GCVIERAFKD EYMVNLVRAP EVPVISGAFC YDVVLDSKLD EWMPTKENLR SFTKDAHALI YKDLPFETLE VEAKVALEIF QHSKYKVDFI EEKASQNPER IVKLHRIGDF IDVSEGPLIP RTSICFQYEV SAVHNLQPTQ PSLIRRFQGV SLPVHLRAHF TIWDKLLERS RKMVTEDQSK ATEECTST
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Molecular Weight
38.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRPL39 (Mitochondrial Ribosomal Protein L39) is a component of the mitochondrial ribosome, which plays a crucial role in protein synthesis within mitochondria. This protein is integral for translating mitochondrial DNA-encoded genes, contributing significantly to mitochondrial function and cellular metabolism. Recent studies have highlighted the importance of MRPL39 in various cellular processes, including energy production, apoptosis, and the maintenance of mitochondrial integrity. Dysregulation of mitochondrial function has been linked to numerous diseases, including neurodegenerative disorders and certain cancers. As such, understanding the structure and function of MRPL39 is critical for elucidating the mechanisms underlying mitochondrial dysfunction. Researchers have focused on the recombinant expression of MRPL39 to investigate its biological roles and interactions at the molecular level. The production of MRPL39 as a recombinant protein allows for further characterization through biochemical assays and structural studies, providing insights into its specific functions in mitochondrial translation and its potential involvement in disease pathways. Overall, the research on MRPL39 not only enhances our understanding of mitochondrial biology but may also pave the way for developing targeted therapies for mitochondrial-related diseases.
