Analytical Data
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基因名
GBP2
- Application
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别名
GBP2；Guanylate-binding Protein 2
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P32456
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表达区间
1-588aa
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氨基酸序列
MAPEINLPGP MSLIDNTKGQ LVVNPEALKI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG KKNGFSLGS TVKSHTKGIW MWCVPHPKKP EHTLVLLDTE GLGDIEKGDN ENDSWIFALA ILLSSTFVY NSMGTINQQA MDQLHYVTEL TDRIKANSSP GNNSVDDSAD FVSFFPAFVW TLRDFTLEL EVDGEPITAD DYLELSLKLR KGTDKKSKSF NDPRLCIRKF FPKRKCFVFD WPAPKKYLA HLEQLKEEEL NPDFIEQVAE FCSYILSHSN VKTLSGGIPV NGPRLESLVL TYVNAISSG DLPCMENAVL ALAQIENSAA VEKAIAHYEQ QMGQKVQLPT ETLQELLDLH RDSEREAIE VFMKNSFKDV DQMFQRKLGA QLEARRDDFC KQNSKASSDC CMALLQDIFG PLEEDVKQG TFSKPGGYRL FTQKLQELKN KYYQVPRKGI QAKEVLKKYL ESKEDVADAL LQTDQSLSE KEKAIEVERI KAESAEAAKK MLEEIQKKNE EMMEQKEKSY QEHVKQLTEK MERDRAQLM AEQEKTLALK LQEQERLLKE GFENESKRLQ KDIWDIQMRS KSLEPIC
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分子量
68 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GBP2 (Guanylate Binding Protein 2) is a member of the GBP family, which plays a crucial role in the immune response, particularly in the defense against intracellular pathogens. This protein is known for its ability to bind nucleotides, and its expression is prominently induced by interferons, highlighting its significance in antiviral responses. Research has shown that GBP2 is involved in various cellular processes, including autophagy, inflammation, and apoptosis, making it a pivotal player in the host immune system. The study of GBP2’s structure and function has garnered attention due to its potential as a therapeutic target for infectious diseases and inflammatory disorders. Furthermore, its role in the pathogenesis of certain diseases, such as cancer, underscores the need for a comprehensive understanding of its regulatory mechanisms. Recent advances in structural biology, such as X-ray crystallography and cryo-electron microscopy, have provided insights into the molecular mechanisms by which GBP2 interacts with other proteins and cellular structures. Understanding GBP2 is fundamental for developing novel strategies to enhance immune responses and devise new treatments for diseases linked to its dysfunction. The ongoing research aims to delineate the signaling pathways influenced by GBP2, thereby uncovering its potential dual roles in health and disease.
