Analytical Data
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Gene name
GBP2
- Application
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Alternative Names
GBP2；Guanylate-binding Protein 2
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P32456
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Expression Region
1-588aa
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AA Sequence
MAPEINLPGP MSLIDNTKGQ LVVNPEALKI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG KKNGFSLGS TVKSHTKGIW MWCVPHPKKP EHTLVLLDTE GLGDIEKGDN ENDSWIFALA ILLSSTFVY NSMGTINQQA MDQLHYVTEL TDRIKANSSP GNNSVDDSAD FVSFFPAFVW TLRDFTLEL EVDGEPITAD DYLELSLKLR KGTDKKSKSF NDPRLCIRKF FPKRKCFVFD WPAPKKYLA HLEQLKEEEL NPDFIEQVAE FCSYILSHSN VKTLSGGIPV NGPRLESLVL TYVNAISSG DLPCMENAVL ALAQIENSAA VEKAIAHYEQ QMGQKVQLPT ETLQELLDLH RDSEREAIE VFMKNSFKDV DQMFQRKLGA QLEARRDDFC KQNSKASSDC CMALLQDIFG PLEEDVKQG TFSKPGGYRL FTQKLQELKN KYYQVPRKGI QAKEVLKKYL ESKEDVADAL LQTDQSLSE KEKAIEVERI KAESAEAAKK MLEEIQKKNE EMMEQKEKSY QEHVKQLTEK MERDRAQLM AEQEKTLALK LQEQERLLKE GFENESKRLQ KDIWDIQMRS KSLEPIC
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Molecular Weight
68 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
GBP2 (Guanylate Binding Protein 2) is a member of the GBP family, which plays a crucial role in the immune response, particularly in the defense against intracellular pathogens. This protein is known for its ability to bind nucleotides, and its expression is prominently induced by interferons, highlighting its significance in antiviral responses. Research has shown that GBP2 is involved in various cellular processes, including autophagy, inflammation, and apoptosis, making it a pivotal player in the host immune system. The study of GBP2’s structure and function has garnered attention due to its potential as a therapeutic target for infectious diseases and inflammatory disorders. Furthermore, its role in the pathogenesis of certain diseases, such as cancer, underscores the need for a comprehensive understanding of its regulatory mechanisms. Recent advances in structural biology, such as X-ray crystallography and cryo-electron microscopy, have provided insights into the molecular mechanisms by which GBP2 interacts with other proteins and cellular structures. Understanding GBP2 is fundamental for developing novel strategies to enhance immune responses and devise new treatments for diseases linked to its dysfunction. The ongoing research aims to delineate the signaling pathways influenced by GBP2, thereby uncovering its potential dual roles in health and disease.
