Analytical Data
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基因名
GBP3
- Application
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别名
GBP3；Guanylate-binding Protein 3
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H0R5
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表达区间
1-595aa
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氨基酸序列
MAPEIHMTGP MCLIENTNGE LVANPEALKI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG KNKGFSLGST VKSHTKGIWM WCVPHPKKPE HTLVLLDTEG LGDVKKGDNQ NDSWIFTLAV LLSSTLVYNS MGTINQQAMD QLYYVTELTH RIRSKSSPDE NENEDSADFV SFFPDFVWTL RDFSLDLEAD GQPLTPDEYL EYSLKLTQGT SQKDKNFNLP RLCIRKFFPK KKCFVFDLPI HRRKLAQLEK LQDEELDPEF VQQVADFCSY IFSNSKTKTL SGGIKVNGPR LESLVLTYIN AISRGDLPCM ENAVLALAQI ENSAAVQKAI AHYDQQMGQK VQLPAETLQE LLDLHRVSER EATEVYMKNS FKDVDHLFQK KLAAQLDKKR DDFCKQNQEA SSDRCSALLQ VIFSPLEEEV KAGIYSKPGG YCLFIQKLQD LEKKYYEEPR KGIQAEEILQ TYLKSKESVT DAILQTDQIL TEKEKEIEVE CVKAESAQAS AKMVEEMQIK YQQMMEEKEK SYQEHVKQLT EKMERERAQL LEEQEKTLTS KLQEQARVLK ERCQGESTQL QNEIQKLQKT LKKKTKRYMS HKLKI
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分子量
68.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GBP3 (Guanylate-binding protein 3) is a member of the guanylate-binding protein family, known for its role in the immune response and regulation of inflammation. Research into GBP3 has gained traction due to its involvement in various cellular processes, such as macrophage activation, antiviral defense, and the modulation of intracellular signaling pathways. GBP3 functions as an effector molecule that is induced by interferons, playing a crucial role in innate immunity against bacterial and viral infections. Its unique GTP-binding and hydrolysis capabilities suggest potential implications in membrane dynamics and cell signaling. Additionally, GBP3 has been implicated in several disease contexts, including autoimmune disorders and cancer, making it a candidate for therapeutic interventions. Studies utilizing recombinant GBP3 have provided insights into its structural characteristics and functional mechanisms, paving the way for further investigations into its potential applications in immunotherapy and disease treatment. Understanding the mechanisms by which GBP3 exerts its effects could lead to novel strategies for enhancing immune responses and developing new treatments for infectious diseases and immune-related conditions.
