Analytical Data
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Gene name
MRPL24
- Application
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Alternative Names
MRPL24; 39S ribosomal protein L24; mitochondrial; L24mt; MRP-L24; Mitochondrial large ribosomal subunit protein uL24m
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q96A35
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Expression Region
10-216 aa
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AA Sequence
A SKVTLPPHYR YGMSPPGSVA DKRKNPPWIR RRPVVVEPIS DEDWYLFCGD TVEILEGKDA GKQGKVVQVI RQRNWVVVGG LNTHYRYIGK TMDYRGTMIP SEAPLLHRQV KLVDPMDRKP TEIEWRFTEA GERVRVSTRS GRIIPKPEFP RADGIVPETW IDGPKDTSVE DALERTYVPC LKTLQEEVME AMGIKETRKY KKVYWY
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Molecular Weight
24.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRPL24, or mitochondrial ribosomal protein L24, is a critical component of the mitochondrial ribosome, playing a vital role in the process of mitochondrial protein synthesis. Given that mitochondria are often referred to as the powerhouses of the cell, producing adenosine triphosphate (ATP) through oxidative phosphorylation, the function of MRPL24 is essential for cellular energy metabolism. Research into MRPL24 has revealed its involvement in various biological processes, including mitochondrial biogenesis and the regulation of apoptosis. Abnormalities or mutations in MRPL24 have been implicated in several mitochondrial disorders and diseases, particularly those related to energy metabolism and aging. The study of MRPL24 as a recombinant protein is gaining traction as it allows researchers to better understand its structure, function, and interactions with other mitochondrial components. By expressing MRPL24 in suitable systems, scientists can investigate its role in mitochondrial translation and analyze how it affects the assembly of the mitochondrial ribosome. Furthermore, understanding MRPL24's interactions at the molecular level can provide insights into the mechanisms of diseases associated with mitochondrial dysfunction. This research not only enhances our comprehension of basic mitochondrial biology but also opens avenues for potential therapeutic interventions in mitochondrial diseases. The study of MRPL24 as a recombinant protein thus represents a promising area of investigation in both fundamental and applied biomedical research.
