Analytical Data
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基因名
MRPL24
- Application
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别名
MRPL24; 39S ribosomal protein L24; mitochondrial; L24mt; MRP-L24; Mitochondrial large ribosomal subunit protein uL24m
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96A35
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表达区间
10-216 aa
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氨基酸序列
A SKVTLPPHYR YGMSPPGSVA DKRKNPPWIR RRPVVVEPIS DEDWYLFCGD TVEILEGKDA GKQGKVVQVI RQRNWVVVGG LNTHYRYIGK TMDYRGTMIP SEAPLLHRQV KLVDPMDRKP TEIEWRFTEA GERVRVSTRS GRIIPKPEFP RADGIVPETW IDGPKDTSVE DALERTYVPC LKTLQEEVME AMGIKETRKY KKVYWY
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分子量
24.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRPL24, or mitochondrial ribosomal protein L24, is a critical component of the mitochondrial ribosome, playing a vital role in the process of mitochondrial protein synthesis. Given that mitochondria are often referred to as the powerhouses of the cell, producing adenosine triphosphate (ATP) through oxidative phosphorylation, the function of MRPL24 is essential for cellular energy metabolism. Research into MRPL24 has revealed its involvement in various biological processes, including mitochondrial biogenesis and the regulation of apoptosis. Abnormalities or mutations in MRPL24 have been implicated in several mitochondrial disorders and diseases, particularly those related to energy metabolism and aging. The study of MRPL24 as a recombinant protein is gaining traction as it allows researchers to better understand its structure, function, and interactions with other mitochondrial components. By expressing MRPL24 in suitable systems, scientists can investigate its role in mitochondrial translation and analyze how it affects the assembly of the mitochondrial ribosome. Furthermore, understanding MRPL24's interactions at the molecular level can provide insights into the mechanisms of diseases associated with mitochondrial dysfunction. This research not only enhances our comprehension of basic mitochondrial biology but also opens avenues for potential therapeutic interventions in mitochondrial diseases. The study of MRPL24 as a recombinant protein thus represents a promising area of investigation in both fundamental and applied biomedical research.
