Analytical Data
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基因名
GBP6
- Application
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别名
GBP6；Guanylate-binding Protein 6
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6ZN66
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表达区间
1-633aa
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氨基酸序列
MESGPKMLAP VCLVENNNEQ LLVNQQAIQI LEKISQPVVV VAIVGLYRTG KSYLMNHLAG QNHGFPLGST VQSETKGIWM WCVPHPSKPN HTLVLLDTEG LGDVEKGDPK NDSWIFALAV LLCSTFVYNS MSTINHQALE QLHYVTELTE LIKAKSSPRP DGVEDSTEFV SFFPDFLWTV RDFTLELKLN GHPITEDEYL ENALKLIQGN NPRVQTSNFP RECIRRFFPK RKCFVFDRPT NDKDLLANIE KVSEKQLDPK FQEQTNIFCS YIFTHARTKT LREGITVTGN RLGTLAVTYV EAINSGAVPC LENAVITLAQ RENSAAVQRA ADYYSQQMAQ RVKLPTDTLQ ELLDMHAACE REAIAIFMEH SFKDENQEFQ KKFMETTMNK KGDFLLQNEE SSVQYCQAKL NELSKGLMES ISAGSFSVPG GHKLYMETKE RIEQDYWQVP RKGVKAKEVF QRFLESQMVI EESILQSDKA LTDREKAVAV DRAKKEAAEK EQELLKQKLQ EQQQQMEAQD KSRKENIAQL KEKLQMEREH LLREQIMMLE HTQKVQNDWL HEGFKKKYEE MNAEISQFKR MIDTTKNDDT PWIARTLDNL ADELTAILSA PAKLIGHGVK GVSSLFKKHK LPF
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分子量
72.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The GBP6 protein, belonging to the Guanylate-binding protein (GBP) family, has garnered significant attention in the realm of immunology and cell biology due to its crucial role in the innate immune response and its potential implications in various diseases, including infections and cancer. As part of the host defense mechanism, GBP6 is known to be activated by interferon-gamma (IFN-γ) and is involved in the regulation of inflammation and the antimicrobial response. Its ability to bind guanosine triphosphate (GTP) suggests that it may play a role in cellular signaling pathways related to cellular stress and immune modulation. Additionally, recent studies have indicated that GBP6 can influence the dynamics of the cytoskeleton and vesicular transport, further underscoring its significance in maintaining cellular homeostasis. The investigation into GBP6 is particularly relevant as researchers seek to understand its interactions with pathogens and its function in various pathological states, including its involvement in autoimmune disorders. Advances in molecular techniques and structural biology have facilitated the exploration of GBP6's structural characteristics and functional mechanisms, which may pave the way for novel therapeutic strategies targeting GBP6-related pathways. As the scientific community continues to unravel the complexities of host-pathogen interactions, GBP6 stands out as a promising candidate for further research, with the potential to contribute to innovative approaches in disease treatment and prevention.
