Analytical Data
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基因名
CYP2A13
- Application
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别名
CYP2A13；Cytochrome P450 2A13
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q16696
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表达区间
1-494aa
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氨基酸序列
MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYTMSFLPR
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分子量
64.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CYP2A13 is a member of the cytochrome P450 superfamily of enzymes, primarily involved in the metabolism of various endogenous and exogenous compounds, including drugs and carcinogens. This enzyme is predominantly expressed in the human respiratory system, particularly in bronchial epithelial cells, which makes it crucial for studying the metabolic activation of tobacco-specific nitrosamines that are implicated in lung cancer. Given the rising incidence of smoking-related diseases, the role of CYP2A13 in detoxifying or bioactivating harmful substances has garnered significant research interest. Understanding CYP2A13's structure, function, and regulation can provide insights into individual variability in drug responses and susceptibility to lung cancer, particularly among smokers. Moreover, CYP2A13 has been shown to exhibit different activity levels among various populations due to genetic polymorphisms, impacting how different individuals metabolize carcinogens. Researchers are focusing on producing recombinant CYP2A13 proteins to study their enzymatic activity, substrate specificity, and inhibitor interactions, facilitating the development of better therapeutic strategies and risk assessments for tobacco-related diseases. The findings related to CYP2A13 can potentially inform personalized medicine approaches and contribute to reducing the impact of tobacco use on public health.
