Analytical Data
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基因名
GBP7
- Application
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别名
GBP7；GBP4L；Guanylate-binding Protein 7
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N8V2
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表达区间
1-638aa
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氨基酸序列
MASEIHMPGP VCLTENTKGH LVVNSEALEI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG KNKGFPLGCT VKSETKGIWM WCVPHPSKPN HTLILLDTEG LGDMEKSDPK SDSWIFALAV LLSSSFVYNS MGTINHQALE QLHYVTELTE LIRAKSCPRP DEVEDSSEFV SFFPDFIWTV RDFTLELKLD GHPITEDEYL ENALKLISGK NPQIQNSNKP REWIRHFFPK QKCFVFDRPI NDKKLLLHVE EVREDQLDSN FQMQSENFCS YIFTHAKTKT LREGILVTGN RLGMLVETYL DAINSGATPC LENAMAVLAQ CENSAAVQRA ANHYSQQMAQ QVRFPTDTLQ ELLDVHAVCE REAIAVFMEY SFKDKSQEFQ KKLVDTMEKK KEDFVLQNEE ASAKYCQAEL KRLSELLTES ISRGTFFVPG GHNIYLEAKK KIEQDYTLVP RKGVKADEVL QSFLQSQVVI EESILQSDKA LTAGEKAIAA KQAKKEAAEK EQELLRQKQK EQQQMMEAQE RSFQENIAQL KKKMEREREN YMRELRKMLS HKMKVLEELL TEGFKEIFES LNEEINRLKE QIEAAENEEP SVFSQILDVA GSIFIAALPG AAKLVDLGMK ILSSLCNRLR NPGKKIIS
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分子量
72.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GBP7 (Guanylate Binding Protein 7) is a member of the guanylate-binding protein family, which plays a pivotal role in the host's immune response against various pathogens. These proteins are known for their GTPase activity and are involved in the regulation of numerous processes, including inflammation and cell survival. GBP7 has garnered attention within the scientific community due to its potential role in anti-viral immunity and its association with several diseases, including autoimmune disorders and cancer. Research indicates that GBP7 can modulate immune responses by enhancing the production of pro-inflammatory cytokines and promoting the activation of immune cells, thus playing an essential part in the defense mechanisms of the host. Studies have shown that GBP7 is induced by the activation of certain immune pathways, particularly in response to interferons, suggesting its involvement in the antiviral response. Furthermore, understanding the molecular mechanisms underlying GBP7's function could unlock new therapeutic avenues for diseases linked to immune dysregulation. Given the escalating need for innovative treatments for viral infections and immune-related disorders, GBP7 represents a promising target for future research. This focus on GBP7’s structure and function aims to unravel its role more intricately and explore its potential as a biomarker or therapeutic target for enhancing immune responses. As research continues, the implications of GBP7 in both innate and adaptive immunity highlight its significance in developing novel immunotherapies and vaccines.
