Analytical Data
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Gene name
MRPL21
- Application
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Alternative Names
MRPL21; 39S ribosomal protein L21; mitochondrial; L21mt; MRP-L21; Mitochondrial large ribosomal subunit protein bL21m
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q7Z2W9
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Expression Region
40-205 aa
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AA Sequence
N SQSTSYLPGY VPKTSLSSPP WPEVVLPDPV EETRHHAEVV KKVNEMIVTG QYGRLFAVVH FASRQWKVTS EDLILIGNEL DLACGERIRL EKVLLVGADN FTLLGKPLLG KDLVRVEATV IEKTESWPRI IMRFRKRKNF KKKRIVTTPQ TVLRINSIEI APCLL
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Molecular Weight
22.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MRPL21, a gene encoding a mitochondrial ribosomal protein, has garnered increasing attention in recent research due to its critical role in mitochondrial function and cellular metabolism. Mitochondria are the powerhouse of the cell, and their dysfunction is associated with a range of diseases, including neurodegenerative disorders, metabolic syndromes, and cancer. The MRPL21 protein is essential for mitochondrial protein synthesis, contributing to the translation of mitochondrial mRNAs which encode vital components of the oxidative phosphorylation pathway. Mutations or dysregulation of MRPL21 have been implicated in various mitochondrial disorders, highlighting the importance of understanding its structure and function. Recent advances in recombinant protein technology have facilitated the production and purification of MRPL21, enabling researchers to delve deeper into its biochemical properties and interactions with other mitochondrial components. Studying the recombinant MRPL21 protein provides insights into its role in mitochondrial ribosome assembly, protein synthesis, and potential implications in disease pathology. This research not only enhances our understanding of mitochondrial biology but also opens avenues for therapeutic interventions targeting mitochondrial dysfunction. As such, MRPL21 stands as a promising candidate for further exploration in both fundamental research and translational studies aimed at addressing mitochondrial-related diseases.
