Analytical Data
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基因名
MRPL18
- Application
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别名
39S ribosomal protein L18; 39S ribosomal protein L18 mitochondrial ; 39S ribosomal protein L18; mitochondrial precursor; HSPC071; L18mt; mitochondrial; Mitochondrial ribosomal protein L18 ; Mitochondrial ribosomal protein L18 (MRPL18 protein); MRP-L18; Mrpl18; RM18_HUMAN; RP1 195P10.3 001
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9H0U6
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表达区间
1-180 aa
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氨基酸序列
MALRSRFWGLFSVCRNPGCRFAALSTSSEPAAKPEVDPVENEAVAPEFTNRNPRNLELLSVARKERGWRTVFPSREFWHRLRVIRTQHHVEALVEHQNGKVVVSASTREWAIKKHLYSTRNVVACESIGRVLAQRCLEAGINFMVYQPTPWEAASDSMKRLQSAMTEGGVVLREPQRIYE
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分子量
47 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRPL18, or Mitochondrial Ribosomal Protein L18, is a crucial component of the mitochondrial ribosome, which plays a significant role in protein synthesis within mitochondria. The study of MRPL18 has gained attention due to its potential implications in mitochondrial function, energy metabolism, and various diseases, including neurodegenerative disorders and cancer. Mitochondria are essential organelles responsible for producing adenosine triphosphate (ATP), the primary energy currency of the cell, and their dysfunction is linked to a range of pathologies. Research has shown that defects in mitochondrial ribosomal proteins, such as MRPL18, can lead to impaired mitochondrial translation and subsequently affect overall cellular metabolism and health. Moreover, MRPL18 has been implicated in the regulation of oxidative stress responses, making it a candidate for further investigation in the context of aging and mitochondrial-related diseases. Understanding the structure and function of MRPL18, as well as its interactions with other mitochondrial components, may provide insights into therapeutic strategies for mitigating mitochondrial dysfunction and associated diseases. As a result, ongoing studies aim to elucidate the precise role of MRPL18 in cellular metabolism and its potential as a biomarker or therapeutic target in mitochondrial pathologies.
