Analytical Data
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Gene name
MRPL18
- Application
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Alternative Names
39S ribosomal protein L18; 39S ribosomal protein L18 mitochondrial ; 39S ribosomal protein L18; mitochondrial precursor; HSPC071; L18mt; mitochondrial; Mitochondrial ribosomal protein L18 ; Mitochondrial ribosomal protein L18 (MRPL18 protein); MRP-L18; Mrpl18; RM18_HUMAN; RP1 195P10.3 001
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H0U6
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Expression Region
1-180 aa
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AA Sequence
MALRSRFWGLFSVCRNPGCRFAALSTSSEPAAKPEVDPVENEAVAPEFTNRNPRNLELLSVARKERGWRTVFPSREFWHRLRVIRTQHHVEALVEHQNGKVVVSASTREWAIKKHLYSTRNVVACESIGRVLAQRCLEAGINFMVYQPTPWEAASDSMKRLQSAMTEGGVVLREPQRIYE
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Molecular Weight
47 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MRPL18, or Mitochondrial Ribosomal Protein L18, is a crucial component of the mitochondrial ribosome, which plays a significant role in protein synthesis within mitochondria. The study of MRPL18 has gained attention due to its potential implications in mitochondrial function, energy metabolism, and various diseases, including neurodegenerative disorders and cancer. Mitochondria are essential organelles responsible for producing adenosine triphosphate (ATP), the primary energy currency of the cell, and their dysfunction is linked to a range of pathologies. Research has shown that defects in mitochondrial ribosomal proteins, such as MRPL18, can lead to impaired mitochondrial translation and subsequently affect overall cellular metabolism and health. Moreover, MRPL18 has been implicated in the regulation of oxidative stress responses, making it a candidate for further investigation in the context of aging and mitochondrial-related diseases. Understanding the structure and function of MRPL18, as well as its interactions with other mitochondrial components, may provide insights into therapeutic strategies for mitigating mitochondrial dysfunction and associated diseases. As a result, ongoing studies aim to elucidate the precise role of MRPL18 in cellular metabolism and its potential as a biomarker or therapeutic target in mitochondrial pathologies.
