Analytical Data
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Gene name
PPP6C
- Application
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Alternative Names
PPP6C；PPP6；Serine/threonine-Protein phosphatase 6 catalytic subunit
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O00743
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Expression Region
1-305aa
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AA Sequence
MAPLDLDKYV EIARLCKYLP ENDLKRLCDY VCDLLLEESN VQPVSTPVTV CGDIHGQFYD LCELFRTGGQ VPDTNYIFMG DFVDRGYYSL ETFTYLLALK AKWPDRITLL RGNHESRQIT QVYGFYDECQ TKYGNANAWR YCTKVFDMLT VAALIDEQIL CVHGGLSPDI KTLDQIRTIE RNQEIPHKGA FCDLVWSDPE DVDTWAISPR GAGWLFGAKV TNEFVHINNL KLICRAHQLV HEGYKFMFDE KLVTVWSAPN YCYRCGNIAS IMVFKDVNTR EPKLFRAVPD SERVIPPRTT TPYFL
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Molecular Weight
35.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PPP6C (Protein Phosphatase 6 Catalytic Subunit) is an important serine/threonine phosphatase that plays a crucial role in various cellular processes, including cell cycle regulation, DNA damage response, and immune signaling. Research into PPP6C has gained prominence due to its involvement in several pathophysiological conditions, such as cancer, where it can influence tumor progression and resistance to therapies. Recent studies have highlighted the significance of PPP6C in modulating signaling pathways, including those associated with the mTOR pathway and immune checkpoint regulation, making it a potential target for therapeutic intervention. Additionally, mutations and dysregulation of PPP6C have been linked to specific cancers, further underscoring the need for in-depth studies on this protein. The recombinant expression of PPP6C provides an essential tool for investigating its biochemical properties, interaction with other signaling molecules, and potential as a drug target. Understanding the structure and function of PPP6C through recombinant protein studies can pave the way for novel therapeutic strategies aimed at diseases where PPP6C is implicated, thus providing insights into its role in cellular homeostasis and disease pathology.
