Analytical Data
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基因名
PPP6C
- Application
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别名
PPP6C；PPP6；Serine/threonine-Protein phosphatase 6 catalytic subunit
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O00743
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表达区间
1-305aa
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氨基酸序列
MAPLDLDKYV EIARLCKYLP ENDLKRLCDY VCDLLLEESN VQPVSTPVTV CGDIHGQFYD LCELFRTGGQ VPDTNYIFMG DFVDRGYYSL ETFTYLLALK AKWPDRITLL RGNHESRQIT QVYGFYDECQ TKYGNANAWR YCTKVFDMLT VAALIDEQIL CVHGGLSPDI KTLDQIRTIE RNQEIPHKGA FCDLVWSDPE DVDTWAISPR GAGWLFGAKV TNEFVHINNL KLICRAHQLV HEGYKFMFDE KLVTVWSAPN YCYRCGNIAS IMVFKDVNTR EPKLFRAVPD SERVIPPRTT TPYFL
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分子量
35.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PPP6C (Protein Phosphatase 6 Catalytic Subunit) is an important serine/threonine phosphatase that plays a crucial role in various cellular processes, including cell cycle regulation, DNA damage response, and immune signaling. Research into PPP6C has gained prominence due to its involvement in several pathophysiological conditions, such as cancer, where it can influence tumor progression and resistance to therapies. Recent studies have highlighted the significance of PPP6C in modulating signaling pathways, including those associated with the mTOR pathway and immune checkpoint regulation, making it a potential target for therapeutic intervention. Additionally, mutations and dysregulation of PPP6C have been linked to specific cancers, further underscoring the need for in-depth studies on this protein. The recombinant expression of PPP6C provides an essential tool for investigating its biochemical properties, interaction with other signaling molecules, and potential as a drug target. Understanding the structure and function of PPP6C through recombinant protein studies can pave the way for novel therapeutic strategies aimed at diseases where PPP6C is implicated, thus providing insights into its role in cellular homeostasis and disease pathology.
