Analytical Data
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Gene name
MRPL17
- Application
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Alternative Names
MRPL17; LIP2; 39S ribosomal protein L17; mitochondrial; L17mt; MRP-L17; LYST-interacting protein 2; Mitochondrial large ribosomal subunit protein bL17m
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NRX2
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Expression Region
9-175 aa
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AA Sequence
IS HGRVFRRMGL GPESRIHLLR NLLTGLVRHE RIEAPWARVD EMRGYAEKLI DYGKLGDTNE RAMRMADFWL TEKDLIPKLF QVLAPRYKDQ TGGYTRMLQI PNRSLDRAKM AVIEYKGNCL PPLPLPRRDS HLTLLNQLLQ GLRQDLRQSQ EASNHSSHTA QTPGI
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Molecular Weight
20.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MRPL17, a member of the mitochondrial ribosomal protein family, plays a crucial role in mitochondrial protein synthesis and overall cellular metabolism. Mitochondria, often referred to as the powerhouse of the cell, are essential for ATP production and the regulation of apoptosis, making the proteins involved in their function critically important. Abnormalities in mitochondrial protein synthesis can lead to a range of diseases, including neurodegenerative disorders and cardiomyopathies. Research into MRPL17 has gained attention due to its potential implications in mitochondrial dysfunction and related pathologies. Previous studies have highlighted its role in stabilizing mitochondrial ribosomes and influencing the translation of mitochondrial mRNAs. Moreover, variations in MRPL17 expression have been implicated in various diseases, suggesting its significance as a biomarker or therapeutic target. Investigating the structural and functional aspects of MRPL17, including its interactions with other mitochondrial components, could provide insights into mitochondrial biology and aid in the development of strategies for treating mitochondrial-related diseases. Understanding MRPL17 at the molecular level not only sheds light on its specific functions but may also reveal broader mechanisms governing mitochondrial health and cellular energy dynamics. Thus, the ongoing research endeavors surrounding MRPL17 hold promise for advancing our understanding of mitochondrial biology and addressing related health challenges.
