Analytical Data
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基因名
CABP1
- Application
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别名
CABP1;Calcium-binding Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P29377
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表达区间
1-79aa
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氨基酸序列
MSTKKSPEELKRIFEKYAAKEGDPDQLSKDELKLLIQAEFPSLLKGPNTLDDLFQELDKNGDGEVSFEEFQVLVKKISQ
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分子量
9.0 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CABP1 (Calcium Binding Protein 1) is a member of the calmodulin superfamily of calcium-binding proteins, playing a crucial role in calcium signaling and neuronal function. Its expression is predominantly found in the brain, suggesting a significant involvement in synaptic transmission and plasticity. Recent research has highlighted CABP1's potential influence on the modulation of ion channels, particularly in relation to voltage-gated calcium channels, which are vital for excitatory neurotransmitter release and muscle contraction. Mutations or dysregulation of CABP1 have been associated with various neurological disorders, including autism spectrum disorders and other neurodevelopmental conditions. The recombinant expression of CABP1 has thus become a focal point for understanding its biochemical properties and physiological roles. By producing CABP1 in a laboratory setting, researchers can study its structure-function relationships, elucidate its interactions with target proteins, and ultimately assess its impact on cellular signaling pathways. This research not only sheds light on the fundamental biology of calcium signaling but also opens avenues for therapeutic interventions targeting CABP1-related pathologies. Understanding CABP1's role in the nervous system could potentially lead to novel strategies for managing neurological diseases, highlighting the importance of this protein in both basic and applied research realms.












