Analytical Data
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Gene name
NR0B1
- Application
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Alternative Names
NR0B1；AHC；DAX1；Nuclear receptor subfamily 0 group B member 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P51843
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Expression Region
1-470aa
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AA Sequence
MAGENHQWQGSILYNMLMSAKQTRAAPEAPETRLVDQCWGCSCGDEPGVG REGLLGGRNVALLYRCCFCGKDHPRQGSILYSMLTSAKQTYAAPKAPEAT LGPCWGCSCGSDPGVGRAGLPGGRPVALLYRCCFCGEDHPRQGSILYSLL TSSKQTHVAPAAPEARPGGAWWDRSYFAQRPGGKEALPGGRATALLYRCC FCGEDHPQQGSTLYCVPTSTNQAQAAPEERPRAPWWDTSSGALRPVALKS PQVVCEAASAGLLKTLRFVKYLPCFQVLPLDQQLVLVRNCWASLLMLELA QDRLQFETVEVSEPSMLQKILTTRRRETGGNEPLPVPTLQHHLAPPAEAR KVPSASQVQAIKCFLSKCWSLNISTKEYAYLKGTVLFNPDVPGLQCVKYI QGLQWGTQQILSEHTRMTHQGPHDRFIELNSTLFLLRFINANVIAELFFR PIIGTVSMDDMMLEMLCTKI
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Molecular Weight
78 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NR0B1, also known as DAX1 (Differentiation-Associated Factor 1), is a key transcription factor involved in various biological processes, including development, cell differentiation, and endocrine regulation. It is located on the X chromosome and plays a crucial role in the regulation of steroidogenesis and the development of the hypothalamic-pituitary-gonadal axis. Mutations or disruptions in NR0B1 are linked to several genetic disorders, notably Swyer syndrome, a condition characterized by XY individuals presenting with a female phenotype and gonadal dysgenesis. Research into NR0B1 recombinant protein has gained traction due to its potential implications in understanding gonadal development and function, as well as its role in certain endocrine disorders. Scientists have been focusing on the protein's structure, function, and interaction with other nuclear receptors to elucidate its mechanisms in gene regulation. By studying NR0B1 recombinant protein, researchers aim to develop targeted therapies for conditions arising from its dysfunction, providing insights into treatment options for affected individuals. Additionally, due to its involvement in key developmental processes, NR0B1 serves as a model for investigating transcriptional regulation and the intricate gene networks that govern sexual differentiation and reproductive health. This focus on NR0B1 not only enhances our understanding of human development and disease but also fosters the advancement of biotechnological applications in regenerative medicine and hormonal therapies.
