Analytical Data
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基因名
PPP2R1A
- Application
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别名
PABIR1;C9orf42;FAM122A;PPP2R1A-PPP2R2A-interacting phosphatase regulator 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P30153
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表达区间
1-589aa
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氨基酸序列
MGSSHHHHHHSSGLVPRGSHMGSMAAADGDDSLYPIAVLIDELRNEDVQL RLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFT TLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAH FVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDD TPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEA CVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPE ITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQIL PCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDEC PEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYM PLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEW AHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLR MAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKY FAQEALTVLSLA
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分子量
68 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
PPP2R1A encodes a regulatory subunit of protein phosphatase 2 (PP2A), a critical serine/threonine phosphatase involved in numerous cellular processes, including cell growth, division, and apoptosis. The dysregulation of PP2A has been implicated in various cancers and neurodegenerative diseases, making PPP2R1A a significant focus of research. Mutations in PPP2R1A have been identified in several types of tumors, such as glioblastomas and endometrial cancers, leading to the hypothesis that these alterations may contribute to tumorigenesis by promoting uncontrolled cell proliferation and survival. Understanding the structure and function of PPP2R1A, especially its role in modulating PP2A activity, is critical for elucidating the molecular mechanisms underlying these diseases. The development of recombinant PPP2R1A protein provides a useful tool for investigating its biochemical properties, interactions with other cellular proteins, and its influence on PP2A activity. Researchers are leveraging this recombinant protein to study its potential as a therapeutic target, aiming to restore normal PP2A function in cancer cells and provide insights into novel treatment strategies for diseases linked to PPP2R1A mutations. This research highlights the importance of PPP2R1A in cell signaling pathways and its potential role in cancer therapeutics, offering hope for advancements in precision medicine and targeted therapies.
