Analytical Data
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Gene name
Scamp4
- Application
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Alternative Names
Scamp4；Secretory carrier-associated membrane Protein 4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9JKV5
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Expression Region
1-230aa
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AA Sequence
MAGKENNFPPLPPFLPLKPCFYQDFSDEIPVEHQVLVKRIYRLWMFYCATLGVNLVACLAWWIAGGAGANFGLALLWLVLFTPCSYVCWFRPAYKAFRADSSFNFMTFFFIFGAQFVLTVIQAIGFSGWGACGWLAAVGFFGTSVGAAVVMLVPAILFSLSALVMAVTIVKVHRIYRGAGGSLQKAQTEWSAGTWRNPPSREAQFNSFSGNSLPEYPTVPSYSSSGGHWP
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Molecular Weight
26.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Scamp4 (Secretory Carrier Membrane Protein 4) is a member of the SCAMP protein family, which plays a critical role in intracellular membrane trafficking and endosomal recycling processes. Research on Scamp4 is particularly important due to its involvement in regulating synaptic vesicle dynamics, making it a key player in neuronal communication. Previous studies have highlighted that Scamp proteins, including Scamp4, contribute to the docking and fusion of vesicles with the plasma membrane, facilitating neurotransmitter release and synaptic plasticity, which are essential for learning and memory. Furthermore, alterations in Scamp4 expression or function have been implicated in various neurological disorders, underscoring the relevance of understanding its molecular mechanisms. The recombinant expression of Scamp4 allows for detailed biochemical and biophysical characterization, enabling researchers to explore its structure-function relationships, interactions with other proteins, and its regulatory role in endosomal recycling pathways. This knowledge is crucial in deciphering the complexities of synaptic transmission and could potentially lead to therapeutic strategies for treating cognitive disorders linked to synaptic dysfunction. In summary, studying Scamp4 through recombinant protein techniques provides valuable insights into cellular mechanisms essential for proper neuronal function and holds promise for future research in neurobiology and related therapeutic developments.
