Analytical Data
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Gene name
MNT
- Application
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Alternative Names
Max-binding protein MNT. Class D basic helix-loop-helix protein 3. bHLHd3. Myc antagonist MNT. Protein ROX
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99583
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Expression Region
1-582 aa
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AA Sequence
MSIETLLEAARFLEWQAQQQQRAREEQERLRLEQEREQEQKKANSLARLAHTLPVEEPRMEAPPLPLSPPAPPPAPPPPLATPAPLTVIPIPVVTNSPQPLPPPPPLPAAAQPLPLAPRQPALVGAPGLSIKEPAPLPSRPQVPTPAPLLPDSKATIPPNGSPKPLQPLPTPVLTIAPHPGVQPQLAPQQPPPPTLGTLKLAPAEEVKSSEQKKRPGGIGTREVHNKLEKNRRAHLKECFETLKRNIPNVDDKKTSNLSVLRTALRYIQSLKRKEKEYEHEMERLAREKIATQQRLAELKHELSQWMDVLEIDRVLRQTGQPEDDQASTSTASEGEDNIDEDMEEDRAGLGPPKLSHRPQPELLKSTLPPPSTTPAPLPPHPHPHPHSVALPPAHLPVQQQQPQQKTPLPAPPPPPAAPAQTLVPAPAHLVATAGGGSTVIAHTATTHASVIQTVNHVLQGPGGKHIAHIAPSAPSPAVQLAPATPPIGHITVHPATLNHVAHLGSQLPLYPQPVAVSHIAHTLSHQQVNGTAGLGPPATVMAKPAVGAQVVHHPQLVGQTVLNPVTMVTMPSFPVSTLKLA
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Molecular Weight
88.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MNT (Myc Network Target) is a protein that plays a crucial role in the regulation of gene expression and cellular pathways, particularly in the context of cellular growth, differentiation, and apoptosis. It acts as a transcriptional repressor and is known to interact with various other proteins involved in the Myc signaling network, which is pivotal in cancer biology and the regulation of cell proliferation. Research into MNT and its associated pathways has garnered interest due to the protein's potential implications in tumorigenesis and its ability to influence the balance between cell proliferation and programmed cell death. Studies have indicated that MNT can modulate the activity of oncogenic Myc, thereby providing a unique perspective on how this interaction may be harnessed for therapeutic applications. Understanding MNT's structure, function, and the molecular mechanisms underlying its regulatory roles could pave the way for developing novel strategies in cancer treatment, as well as in regenerative medicine where modulation of cell fate is crucial. Consequently, the study of recombinant MNT proteins has become a focal point in molecular biology research, aiming to elucidate their functionality and explore their potential as biomarkers or therapeutic targets in various diseases.
