Analytical Data
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Gene name
MMP27
- Application
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Alternative Names
EC 3.4.24.; Matrix metallopeptidase 27; Matrix metalloprotease 27; Matrix metalloproteinase 27 ; Matrix metalloproteinase-27; MMP 27; MMP-27; MMP27; MMP27_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9H306
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Expression Region
99-513 aa
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AA Sequence
YG YTLPGWRKYN LTYRIINYTP DMARAAVDEA IQEGLEVWSK VTPLKFTKIS KGIADIMIAF RTRVHGRCPR YFDGPLGVLG HAFPPGPGLG GDTHFDEDEN WTKDGAGFNL FLVAAHEFGH ALGLSHSNDQ TALMFPNYVS LDPRKYPLSQ DDINGIQSIY GGLPKEPAKP KEPTIPHACD PDLTFDAITT FRREVMFFKG RHLWRIYYDI TDVEFELIAS FWPSLPADLQ AAYENPRDKI LVFKDENFWM IRGYAVLPDY PKSIHTLGFP GRVKKIDAAV CDKTTRKTYF FVGIWCWRFD EMTQTMDKGF PQRVVKHFPG ISIRVDAAFQ YKGFFFFSRG SKQFEYDIKT KNITRIMRTN TWFQCKEPKN SSFGFDINKE KAHSGGIKIL YHKSLSLFIF GIVHLLKNTS IYQ
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Molecular Weight
59.0 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MMP27, or Matrix Metalloproteinase 27, is a member of the matrix metalloproteinase (MMP) family, which plays a crucial role in extracellular matrix remodeling and tissue homeostasis. Originally identified in the context of various physiological and pathological processes, including wound healing, tissue repair, and fibrosis, MMP27 has garnered attention due to its potential involvement in cancer progression and metastasis. Unlike other MMPs, MMP27 exhibits unique substrate specificity and regulation, suggesting distinct functional roles in cellular environments. Its expression is often upregulated in several cancer types and inflammatory diseases, indicating its potential as a biomarker for diagnosis and prognosis. Additionally, MMP27 is believed to participate in both normal physiological functions and pathological conditions by modulating the availability of growth factors, influencing cell migration and proliferation. Consequently, the production and characterization of recombinant MMP27 protein have become important for understanding its biological functions and therapeutic potential. Studies involving the recombinant form aim to elucidate its enzymatic activity, substrate interactions, and regulatory mechanisms, paving the way for targeted interventions in diseases linked to aberrant MMP27 expression. This line of research not only contributes to the broader understanding of MMPs in general but also highlights the need for specific therapeutic strategies that can modulate MMP27 activity in clinical settings. Overall, the study of recombinant MMP27 is essential for advancing knowledge in both basic and translational research pertaining to tissue remodeling and disease progression.
