Analytical Data
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Gene name
MMEL1
- Application
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Alternative Names
Mel transforming oncogene like 1; Membrane metallo endopeptidase like 1 ; Membrane metallo endopeptidase like 2; Membrane metallo-endopeptidase-like 1; Membrane metallo-endopeptidase-like 2; MMEL1; MMEL1_HUMAN; NEP2; NEP2(m); NEP2(s); NEPII; Neprilysin 2; Neprilysin II; Neprilysin Like 1; Neprilysin-2; Neprilysin-2 secreted; Neprilysin-like Protease beta; Neprilysin-like Protease gamma; NL1; NL2; SEP; soluble form; Soluble secreted endopeptidase
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q495T6
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Expression Region
1-779 aa
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AA Sequence
MGKSEGPVGMVESAGRAGQKRPGFLEGGLLLLLLLVTAALVALGVLYADRRGKQLPRLASRLCFLQEERTFVKRKPRGIPEAQEVSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFACGGWLRRHVIPETNSRYSIFDVLRDELEVILKAVLENSTAKDRPAVEKARTLYRSCMNQSVIEKRGSQPLLDILEVVGGWPVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWNDDQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCLVQEDMVQVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLSSVKIKLLPDEEVVVYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRVNYRKALFGTMVEEVRWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFVETLDELGWIDEESKKKAQEKAMSIREQIGHPDYILEETNRRLDEEYSNLNFSEDLYFENSLQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSWDLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQQLPGLDLTHEQLFFINYAQVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW
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Molecular Weight
115.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
MMEL1, or Metazoa Mitochondrial Ribosome Biogenesis Factor 1, is a crucial protein involved in mitochondrial ribosome assembly and function. Research into MMEL1 has gained importance as mitochondrial dysfunction is increasingly recognized as a key factor in various human diseases, including neurodegenerative disorders, metabolic syndromes, and cancer. Mitochondria, often referred to as the powerhouse of the cell, are essential for energy production and play a vital role in regulating apoptosis, cellular metabolism, and reactive oxygen species (ROS) generation. Understanding MMEL1's role in mitochondrial biogenesis and the regulation of mitochondrial gene expression can provide insights into the underlying mechanisms of mitochondrial pathologies. Recent studies suggest that mutations or dysregulation of MMEL1 may contribute to impaired mitochondrial function and associated diseases. As such, investigating MMEL1 not only enhances our understanding of mitochondrial biology but also highlights potential therapeutic targets for restoring mitochondrial health. Researchers are employing various biochemical, molecular biology, and genetic approaches to elucidate the functional mechanisms of MMEL1 and its interactions within mitochondrial dynamics, paving the way for future advancements in mitochondrial medicine.
