Analytical Data
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Gene name
INSRR
- Application
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Alternative Names
INSRR；IRR；Insulin receptor-related Protein
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P14616
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Expression Region
945-1297aa
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AA Sequence
GKKRNRTLYASVNPEYFSASDMYVPDEWEVPREQISIIRELGQGSFGMVYEGLARGLEAGEESTPVALKTVNELASPRECIEFLKEASVMKAFKCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSHLRSLRPEAENNPGLPQPALGEMIQMAGEIADGMAYLAANKFVHRDLAARNCMVSQDFTVKIGDFGMTRDVYETDYYRKGGKGLLPVRWMAPESLKDGIFTTHSDVWSFGVVLWEIVTLAEQPYQGLSNEQVLKFVMDGGVLEELEGCPLQLQELMSRCWQPNPRLRPSFTHILDSIQEELRPSFRLLSFYYSPECRGARGSLPTTDAEPDSSPTPRDCSPQNGGPGH
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Molecular Weight
65 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
INSRR, or insulin receptor substrate-related protein, has garnered significant attention in recent years due to its crucial role in various cellular signaling pathways related to metabolism and growth. As a member of the insulin receptor substrate (IRS) family, INSRR is implicated in the insulin signaling pathway but has also been shown to interact with other receptors, suggesting a broader functional role. Research indicates that INSRR is involved in cellular processes such as glucose homeostasis, cell proliferation, and differentiation. Dysregulation of this protein has been associated with metabolic disorders, including obesity and type 2 diabetes, as well as certain cancers, making it a potential therapeutic target. The study of INSRR thus spans multiple fields, including endocrinology, oncology, and metabolic research, highlighting the need for a deeper understanding of its structure, function, and interactions. Recent advancements in recombinant protein technology enable researchers to produce INSRR in vitro, facilitating studies on its biochemical properties and potential as a drug target. Ongoing investigations aim to elucidate the specific molecular mechanisms by which INSRR exerts its effects within cells and to explore potential pathways for intervention in diseases linked to its dysregulation.
