Analytical Data
-
Gene name
POR
- Application
-
Alternative Names
VDAC3;Voltage-dependent anion-selective channel Protein 3
-
Species
Human
-
Source
E. coli
-
Tag
His tag N-Terminus
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
P16435
-
Expression Region
2-671aa
-
AA Sequence
INMGDSHVDTSSTVSEAVAEEVSLFSMTDMILFSLIVGLLTYWFLFRKKKEEVPEFTKIQTLTSSVRESSFVEKMKKTGRNIIVFYGSQTGTAEEFANRLSKDAHRYGMRGMSADPEEYDLADLSSLPEIDNALVVFCMATYGEGDPTDNAQDFYDWLQETDVDLSGVKFAVFGLGNKTYEHFNAMGKYVDKRLEQLGAQRIFELGLGDDDGNLEEDFITWREQFWLAVCEHFGVEATGEESSIRQYELVVHTDIDAAKVYMGEMGRLKSYENQKPPFDAKNPFLAAVTTNRKLNQGTERHLMHLELDISDSKIRYESGDHVAVYPANDSALVNQLGKILGADLDVVMSLNNLDEESNKKHPFPCPTSYRTALTYYLDITNPPRTNVLYELAQYASEPSEQELLRKMASSSGEGKELYLSWVVEARRHILAILQDCPSLRPPIDHLCELLPRLQARYYSIASSSKVHPNSVHICAVVVEYETKAGRINKGVATNWLRAKEPVGENGGRALVPMFVRKSQFRLPFKATTPVIMVGPGTGVAPFIGFIQERAWLRQQGKEVGETLLYYGCRRSDEDYLYREELAQFHRDGALTQLNVAFSREQSHKVYVQHLLKQDREHLWKLIEGGAHIYVCGDARNMARDVQNTFYDIVAELGAMEHAQAVDYIKKLMTK
-
Molecular Weight
102.9kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
POR (P450 oxidoreductase) is a critical enzyme that plays an essential role in the electron transfer process required for the activity of various cytochrome P450 enzymes, which are involved in the metabolism of drugs, steroids, and xenobiotics. Given the importance of these metabolic pathways in pharmacology and toxicology, research on POR has garnered significant interest. Mutations in the POR gene can lead to disorders affecting drug metabolism and steroidogenesis, resulting in clinical manifestations such as adrenal insufficiency or altered drug responses. Understanding the structural and functional aspects of POR is crucial for elucidating its role in metabolic diseases and for developing better therapeutic strategies. Recent studies have focused on the expression and purification of recombinant POR to investigate its interaction with P450 enzymes and explore its enzymatic properties. Advances in this area could provide insights into the mechanisms of drug metabolism and the potential for personalized medicine approaches that account for individual variations in metabolic responses. Moreover, the use of recombinant POR in biotechnological applications, such as the bioconversion of organic compounds or in the production of pharmaceuticals, is also an emerging field of interest. Overall, the study of POR and its recombinant forms has far-reaching implications for both basic and applied sciences, making it a significant area of ongoing research.
