Analytical Data
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Gene name
RGS7
- Application
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Alternative Names
RGS7；Regulator of G-Protein signaling 7
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P49802
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Expression Region
1-487aa
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AA Sequence
MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGKSLTSKRLTSLAQSY
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Molecular Weight
60.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RGS7 (Regulator of G protein Signaling 7) is a crucial member of the RGS protein family that acts as a GTPase-activating protein (GAP), modulating the signaling pathways of G protein-coupled receptors (GPCRs). These receptors are pivotal in various physiological processes, including vision, neurotransmission, and immune responses. Dysregulation of RGS7 has been linked to multiple diseases, such as heart disease, neurodegenerative disorders, and certain types of cancer, highlighting the importance of understanding its function and regulation. Recent studies have focused on characterizing RGS7 through recombinant protein technology, which allows for the production of RGS7 in a controlled environment, thereby facilitating the investigation of its biochemical properties and interactions with other signaling molecules. By expressing RGS7 as a recombinant protein, researchers aim to elucidate its structural characteristics, enhance our understanding of its role in GPCR signaling, and identify potential therapeutic targets for diseases associated with its dysfunction. The growing interest in RGS7 as a biomarker and drug target makes the study of its recombinant form essential for advancing both basic research and clinical applications.
