Analytical Data
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Gene name
MIZF
- Application
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Alternative Names
DKFZp434F162; HiNF-P; HINFP; HINFP_HUMAN; Histone H4 gene specific protein HiNF P; Histone H4 transcription factor; Histone nuclear factor P; MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein; MBD2 interacting zinc finger 1; MBD2 interacting zinc finger protein; MBD2-interacting zinc finger protein; Methyl CpG binding protein 2 interacting zinc finger protein; Methyl-CpG-binding protein 2-interacting zinc finger protein; MIZF; ZNF743
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9BQA5
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Expression Region
1-517 aa
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AA Sequence
MPPPGKVPRK ENLWLQCEWG SCSFVCSTME KFFEHVTQHL QQHLHGSGEE EEEEEEDDPL EEEFSCLWQE CGFCSLDSSA DLIRHVYFHC YHTKLKQWGL QALQSQADLG PCILDFQSRN VIPDIPDHFL CLWEHCENSF DNPEWFYRHV EAHSLCCEYE AVGKDNPVVL CGWKGCTCTF KDRSKLREHL RSHTQEKVVA CPTCGGMFAN NTKFLDHIRR QTSLDQQHFQ CSHCSKRFAT ERLLRDHMRN HVNHYKCPLC DMTCPLPSSL RNHMRFRHSE DRPFKCDCCD YSCKNLIDLQ KHLDTHSEEP AYRCDFENCT FSARSLCSIK SHYRKVHEGD SEPRYKCHVC DKCFTRGNNL TVHLRKKHQF KWPSGHPRFR YKEHEDGYMR LQLVRYESVE LTQQLLRQPQ EGSGLGTSLN ESSLQGIILE TVPGEPGRKE EEEEGKGSEG TALSASQDNP SSVIHVVNQT NAQGQQEIVY YVLSEAPGEP PPAPEPPSGG IMEKLQGIAE EPEIQMV
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Molecular Weight
59.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MIZF (Myeloid Zinc Finger Protein) is a crucial transcription factor implicated in the regulation of various biological processes, including immune responses and cell differentiation. Understanding the structure and function of MIZF through recombinant protein technology has garnered significant attention in recent years. Research indicates that MIZF can modulate gene expression in myeloid cells, influencing pathways relevant to leukemia and other hematological disorders. The ability to produce MIZF as a recombinant protein allows for detailed biochemical studies, enabling researchers to explore its interactions with DNA and other proteins, as well as its role in transcriptional regulation. This research is particularly relevant due to the potential therapeutic implications; MIZF's involvement in immune response regulation suggests that modulating its activity could provide novel strategies for treating immune-related diseases or enhancing anti-tumor responses. Moreover, deciphering the mechanisms through which MIZF exerts its effects can lead to a better understanding of myeloid cell biology and contribute to the development of targeted therapies. As such, the study of MIZF, through the lens of recombinant protein research, not only expands our fundamental knowledge of transcriptional regulation but also has the potential to pave the way for innovative medical approaches in hematology and immunology.
