Analytical Data
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Gene name
PLSCR1
- Application
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Alternative Names
PLSCR1;Phospholipid scramblase 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15162
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Expression Region
1-288aa
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AA Sequence
MGSSHHHHHH SSGLVPRGSH MDKQNSQMNA SHPETNLPVG YPPQYPPTAF QGPPGYSGYP GPQVSYPPPP AGHSGPGPAG FPVPNQPVYN QPVYNQPVGA AGVPWMPAPQ PPLNCPPGLE YLSQIDQILI HQQIELLEVL TGFETNNKYE IKNSFGQRVY FAAEDTDCCT RNCCGPSRPF TLRIIDNMGQ EVITLERPLR CSSCCCPCCL QEIEIQAPPG VPIGYVIQTW HPCLPKFTIQ NEKREDVLKI SGPCVVCSCC GDVDFEIKSL DEQCVVGKIS KHWTGILREA FTDADNFGIQ FPLDLDVK
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Molecular Weight
34 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PLSCR1 (phospholipid scramblase 1) is a protein that plays a critical role in maintaining cellular membrane integrity and mediating phospholipid redistribution during various physiological and pathological processes. It is primarily involved in the early stages of apoptosis, where it participates in the scrambling of phospholipids, leading to the exposure of phosphatidylserine on the outer leaflet of the plasma membrane. This exposure serves as an "eat me" signal for immune cells, facilitating the clearance of dying cells. Beyond its role in apoptosis, PLSCR1 is implicated in immune response regulation and has been linked to various diseases, including cancer, cardiovascular disorders, and infectious diseases. Research into PLSCR1 has expanded to include investigations of its potential as a therapeutic target, as manipulating its function may enhance or inhibit apoptotic processes in diseased tissues. The production of recombinant PLSCR1 protein offers valuable insights into its structure-function relationships and interactions with other cellular components. This knowledge is essential for understanding how PLSCR1 mediates its diverse biological functions and may lead to novel strategies for targeting its pathways in disease contexts. Overall, the study of PLSCR1 and its recombinant forms contributes to a deeper understanding of membrane dynamics and the intricate signaling networks that govern cell fate.
