Analytical Data
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Gene name
MIG-6
- Application
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Alternative Names
ERBB receptor feedback inhibitor 1; ERRFI_HUMAN; Errfi1; GENE 33; Gene 33; rat; homolog of; Mig-6; MIG6; mitogen inducible gene 6; mitogen inducible gene 6 protein; Mitogen-inducible gene 6 protein; RALT; receptor-associated late transducer
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9UJM3
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Expression Region
2-462 aa
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AA Sequence
SIAGVAAQE IRVPLKTGFL HNGRAMGNMR KTYWSSRSEF KNNFLNIDPI TMAYSLNSSA QERLIPLGHA SKSAPMNGHC FAENGPSQKS SLPPLLIPPS ENLGPHEEDQ VVCGFKKLTV NGVCASTPPL TPIKNSPSLF PCAPLCERGS RPLPPLPISE ALSLDDTDCE VEFLTSSDTD FLLEDSTLSD FKYDVPGRRS FRGCGQINYA YFDTPAVSAA DLSYVSDQNG GVPDPNPPPP QTHRRLRRSH SGPAGSFNKP AIRISNCCIH RASPNSDEDK PEVPPRVPIP PRPVKPDYRR WSAEVTSSTY SDEDRPPKVP PREPLSPSNS RTPSPKSLPS YLNGVMPPTQ SFAPDPKYVS SKALQRQNSE GSASKVPCIL PIIENGKKVS STHYYLLPER PPYLDKYEKF FREAEETNGG AQIQPLPADC GISSATEKPD SKTKMDLGGH VKRKHLSYVV SP
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Molecular Weight
50.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The MIG-6 protein, known as Mitogen-Inducible Gene 6, has garnered significant attention in the field of molecular biology and cancer research due to its role as a negative regulator of various growth factor signaling pathways. Initially identified as a gene that is upregulated in response to mitogenic stimuli, MIG-6 has been implicated in the modulation of epidermal growth factor receptor (EGFR) signaling, which is critical for normal cellular processes such as proliferation, differentiation, and survival. Dysregulation of MIG-6 expression has been linked to the development and progression of several cancers, including lung and breast tumors. Recent studies have suggested that MIG-6 may serve as a potential biomarker for tumor response to therapies targeting EGFR and its related pathways, underscoring its relevance in clinical settings. Additionally, the investigation of MIG-6's structural and functional properties through recombinant protein expression has provided insights into its mechanism of action, revealing how it interacts with various signaling molecules and transcription factors. By exploring the therapeutic potential of manipulating MIG-6 levels, researchers aim to develop innovative strategies for cancer treatment that could enhance the efficacy of existing therapies and reduce adverse effects.
