Analytical Data
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Gene name
MIER1
- Application
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Alternative Names
MIER1; KIAA1610; Mesoderm induction early response protein 1; Early response 1; Er1; Mi-er1; hMi-er1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8N108
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Expression Region
1-512 aa
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AA Sequence
MAEPSVESSS PGGSATSDDH EFDPSADMLV HDFDDERTLE EEEMMEGETN FSSEIEDLAR EGDMPIHELL SLYGYGSTVR LPEEDEEEEE EEEEGEDDED ADNDDNSGCS GENKEENIKD SSGQEDETQS SNDDPSQSVA SQDAQEIIRP RRCKYFDTNS EVEEESEEDE DYIPSEDWKK EIMVGSMFQA EIPVGICRYK ENEKVYENDD QLLWDPEYLP EDKVIIFLKD ASRRTGDEKG VEAIPEGSHI KDNEQALYEL VKCNFDTEEA LRRLRFNVKA AREELSVWTE EECRNFEQGL KAYGKDFHLI QANKVRTRSV GECVAFYYMW KKSERYDFFA QQTRFGKKKY NLHPGVTDYM DRLLDESESA ASSRAPSPPP TASNSSNSQS EKEDGTVSTA NQNGVSSNGP GEILNKEEVK VEGLHINGPT GGNKKPLHAD MDTNGYETDN LTTDPKLAHM TARNENDFDE KSERPAKRRR VNSNGKESPG SSEFFQEAVS HGKFEELENT DD
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Molecular Weight
57.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MIER1 (Mediator of Interferon Stimulated Genes 1) is a critical protein involved in the regulation of immune responses and gene expression, particularly in the context of interferon signaling pathways. Its role in mediating the cellular response to viral infections and various stressors makes it an important target in immunology and virology research. Studies have shown that MIER1 interacts with numerous transcription factors and co-regulators, influencing the expression of interferon-stimulated genes (ISGs) and potentially modulating inflammatory responses. The understanding of MIER1's functional implications extends to cancer biology, as altered expression of MIER1 has been linked to tumor progression and immune evasion mechanisms. Consequently, the production of recombinant MIER1 protein has gained significance for investigating its molecular function, interaction partners, and potential therapeutic applications. Recent advancements in recombinant protein technology have facilitated the purification and characterization of MIER1, enabling researchers to perform functional assays that elucidate its biological roles. By generating MIER1 as a recombinant protein, scientists can better explore its mechanisms of action, paving the way for innovative strategies in the development of immune-modulatory therapies and vaccines. Overall, the study of MIER1 and its recombinant forms holds promise for advancing our understanding of immune regulation and improving therapeutic outcomes in various diseases, including viral infections and cancer.
