Analytical Data
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Gene name
Gsdma3
- Application
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Alternative Names
Gsdma3；Gsdm3；Gasdermin-A3
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q5Y4Y6
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Expression Region
263-464aa
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AA Sequence
MHEDFKTLKEEVQRETQEVEKLSPVGRSSLLTSLSHLLGKKKELQDLEQKLEGALDKGQKVTLEALPKDVLLSKDAMDAILYFLGALTELTEEQLKILVKSLEKKILPVQLKLVESTLEQNFLQDKEGVFPLQPDLLSSLGEEELTLTEALVGLSGLEVQRSGPQYAWDPDTRHNLCALYAGLSLLHLLSRKSNALTYCALS
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Molecular Weight
26.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
Gsdma3, a member of the Gasdermin family of proteins, has emerged as a focal point of research due to its significant role in immune responses and cell death mechanisms. This protein is particularly intriguing because of its involvement in the process of pyroptosis, a form of programmed cell death associated with inflammation in response to infections and cellular damage. Studies have indicated that mutations in the Gsdma3 gene are linked to autoimmune conditions and inflammatory diseases, suggesting its crucial function in maintaining cellular integrity and homeostasis. The understanding of Gsdma3's structure and function is essential for unraveling its mechanisms in health and disease, making it a potential target for therapeutic interventions. In recent years, advancements in recombinant protein technology have enabled the production and study of Gsdma3 in vitro, providing valuable insights into its biological roles and interactions. This research aims to elucidate the protein's signaling pathways and its effects on different cell types, paving the way for novel treatments for conditions involving dysregulated cell death and inflammation.
